TY - JOUR
T1 - Synthesis and evaluation of antibacterial and antifungal activities of 1,3-disubstituted-4-thioxoimidazolidin-2-one derivatives
AU - El-Sharief, Marwa A.M.Sh
AU - Abbas, Samir Y.
AU - Moussa, Ziad
AU - El-Gammal, Eman W.
AU - El-Sharief, Ahmed M.Sh
N1 - Publisher Copyright:
© 2018 Croatian Chemical Society. All Rights Reserved.
PY - 2018
Y1 - 2018
N2 - 1,3-Disubstituted-4-thioxoimidazolidin-2-one derivatives with various substituents at N 1 and N 3 were synthesized with high yields and excellent purity by the reaction of various N-arylcyanothioformamide derivatives with isocyanate derivatives. The activity of these products as antibacterial and antifungal agents was studied to through some light on structural activity relationship. Some of synthesized compounds showed significant antibacterial and antifungal activities. Most of the imidazole derivatives possess significant antifungal activity aginst S. cerevisiae(MIC 1–10 µg mL –1 ). As comparision with ketoconazole, most of the imidazole derivatives showed activity ranging from 50 % less activity to fourfold activity.
AB - 1,3-Disubstituted-4-thioxoimidazolidin-2-one derivatives with various substituents at N 1 and N 3 were synthesized with high yields and excellent purity by the reaction of various N-arylcyanothioformamide derivatives with isocyanate derivatives. The activity of these products as antibacterial and antifungal agents was studied to through some light on structural activity relationship. Some of synthesized compounds showed significant antibacterial and antifungal activities. Most of the imidazole derivatives possess significant antifungal activity aginst S. cerevisiae(MIC 1–10 µg mL –1 ). As comparision with ketoconazole, most of the imidazole derivatives showed activity ranging from 50 % less activity to fourfold activity.
KW - Antimicrobial activity
KW - Imidazolidineiminothiones
KW - Isocyanates
KW - N-arylcyanothioformamides
UR - http://www.scopus.com/inward/record.url?scp=85062701293&partnerID=8YFLogxK
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U2 - 10.5562/cca3354
DO - 10.5562/cca3354
M3 - Article
AN - SCOPUS:85062701293
SN - 0011-1643
VL - 91
SP - 335
EP - 340
JO - Croatica Chemica Acta
JF - Croatica Chemica Acta
IS - 3
ER -