Abstract
A number of new benzofuran derivatives, ethyl 3-[(alkylamino)methyl]-6-methoxy-1-benzofuran-2-carboxylates (5a-i), were obtained via the reaction between ethyl 3-(bromomethyl)-6-methoxy-1-benzofuran-2-carboxylate (3) and amines or amino acid ethyl esters. In addition, 1,4-bis[(ethyl 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]piperazine (9), N,N′-diethyl-N,N′-bis[(6-methoxy-1-benzofuran-3-yl-2-carboxy late)methyl]but-2-ene-1,4-diamine (10) and 1,2-bis[(ethyl 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]- 1,2-dimethyl-hydrazine (11) were also obtained from the reaction of 3 with diamines. Their in vitro anti-HIV-1 (strain IIIB) and HIV-2 (strain ROD) activities of the synthesized compounds in human T-lymphocyte were tested; ethyl 3-bromomethyl-6-methoxycoumarlate displayed an ability to inhibit HIV-1 and HIV-2 replication in cell culture at non-toxic concentrations.
| Original language | English |
|---|---|
| Pages (from-to) | 1577-1587 |
| Number of pages | 11 |
| Journal | Heterocycles |
| Volume | 71 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2007 |
| Externally published | Yes |
Keywords
- 3-Bromomethyl-2-carbethoxy-6-methoxybenzofuran
- Amino Acid Ethyl Ester
- Benzofuran
- Cyclization
- HIV
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry
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