TY - JOUR
T1 - Synthesis, characterization, and biological studies of organotin(IV) derivatives with o- or p-hydroxybenzoic acids
AU - Hadjikakou, Sotiris K.
AU - Abdellah, Mohamed A.
AU - Hadjiliadis, Nick
AU - Kubicki, Maciej
AU - Bakas, Thomas
AU - Kourkoumelis, Nikolaos
AU - Simos, Yannis V.
AU - Karkabounas, Spyros
AU - Barsan, Mirela M.
AU - Butler, Ian S.
PY - 2009
Y1 - 2009
N2 - Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o- H2 BZA or p- H2 BZA) of formulae [ R2 Sn (HL)2 ] (where H2L = o-H2 BZA and R = Me- (1), n -Bu- (2)); [ R3Sn (HL) ] (where H2L = o- H2 BZA and R = n -Bu- (3), Ph- (4) or H2 L = p- H2 BZA and R = n -Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o- H 2 BZA or p- H2 BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mssbauer spectroscopy, 1H, 119S n-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1-6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC50 value. Also complexes 1-6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one.
AB - Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o- H2 BZA or p- H2 BZA) of formulae [ R2 Sn (HL)2 ] (where H2L = o-H2 BZA and R = Me- (1), n -Bu- (2)); [ R3Sn (HL) ] (where H2L = o- H2 BZA and R = n -Bu- (3), Ph- (4) or H2 L = p- H2 BZA and R = n -Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o- H 2 BZA or p- H2 BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mssbauer spectroscopy, 1H, 119S n-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1-6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC50 value. Also complexes 1-6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one.
UR - http://www.scopus.com/inward/record.url?scp=67650169110&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650169110&partnerID=8YFLogxK
U2 - 10.1155/2009/542979
DO - 10.1155/2009/542979
M3 - Article
AN - SCOPUS:67650169110
SN - 1565-3633
VL - 2009
JO - Bioinorganic Chemistry and Applications
JF - Bioinorganic Chemistry and Applications
M1 - 542979
ER -
