Synthesis of 1-(β-D-glucopyranosyl) pyrimidin-2(1H)-ones from 2-chloropyrimidines

Ibrahim M. Abdou, Lucjan Strekowski, Mohamed F. Abdel-Megeed, Adel M.E. Attia, Mahmoud A. Omara

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Tetra-O-acetyl derivatives 10-12 of the title compounds are easily obtained by hydrolysis of 2-chloropyrimidines 1-3 followed by coupling of the resultant pyrimidin-2(1H)-ones 4-6 with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide under basic conditions (method A) or treatment of 1-3 with potassium trimethylsilanolate followed by coupling of the resultant 2-(trimethylsilyloxy)pyrimidines, without isolation, with β-D-glucose pentaacetate in the presence of tin tetrachloride (method B).

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalHeterocyclic Communications
Issue number4
Publication statusPublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


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