TY - JOUR
T1 - Synthesis of 1-(β-D-glucopyranosyl) pyrimidin-2(1H)-ones from 2-chloropyrimidines
AU - Abdou, Ibrahim M.
AU - Strekowski, Lucjan
AU - Abdel-Megeed, Mohamed F.
AU - Attia, Adel M.E.
AU - Omara, Mahmoud A.
PY - 1997
Y1 - 1997
N2 - Tetra-O-acetyl derivatives 10-12 of the title compounds are easily obtained by hydrolysis of 2-chloropyrimidines 1-3 followed by coupling of the resultant pyrimidin-2(1H)-ones 4-6 with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide under basic conditions (method A) or treatment of 1-3 with potassium trimethylsilanolate followed by coupling of the resultant 2-(trimethylsilyloxy)pyrimidines, without isolation, with β-D-glucose pentaacetate in the presence of tin tetrachloride (method B).
AB - Tetra-O-acetyl derivatives 10-12 of the title compounds are easily obtained by hydrolysis of 2-chloropyrimidines 1-3 followed by coupling of the resultant pyrimidin-2(1H)-ones 4-6 with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide under basic conditions (method A) or treatment of 1-3 with potassium trimethylsilanolate followed by coupling of the resultant 2-(trimethylsilyloxy)pyrimidines, without isolation, with β-D-glucose pentaacetate in the presence of tin tetrachloride (method B).
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M3 - Article
AN - SCOPUS:0007281605
SN - 0793-0283
VL - 3
SP - 295
EP - 300
JO - Heterocyclic Communications
JF - Heterocyclic Communications
IS - 4
ER -