Synthesis of 8,16-dimethyl- and 8,16-dimethoxy- 5,13-di-t- butyl[2.2]metacyclophane-1,2,9,10-tetraone

Ken ichi Tsukamoto, Daniel A. Sahade, Masahiko Taniguchi, Tsuyoshi Sawada, Thies Thiemann, Shuntaro Mataka

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Swem oxidation of 8,16-dimethoxy- and 8,16-dimethyl-5,13-di-t-butyl- l,2,9,10-tetrahydroxy[2.2]metacyclophane, 1 and 2, afforded 5,13-di:t-butyl- 10-hydroxy-8,16-dimethoxy[2.2]metacyclophane-1,2,9-trione 3 and 4. By subsequent oxidation with DDQ, 8,16-dimethoxy- and 8,16-dimethyl-5,13-di-t- butyl[2.2]metacyclophane-1,2,9,10-tetraones, 5 and 6, were obtained.

Original languageEnglish
Pages (from-to)4691-4692
Number of pages2
JournalTetrahedron Letters
Volume40
Issue number25
DOIs
Publication statusPublished - Jun 18 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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