Synthesis of all-trans arachidonic acid and its effect on rabbit platelet aggregation

Dimitris Anagnostopoulos, Chryssostomos Chatgilialoglu, Carla Ferreri, Abdelouahid Samadi, Athanassia Siafaka-Kapadai

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


A simple and high-yielding method to convert natural all-cis PUFA derivatives to the corresponding all-trans geometrical isomers is described. The method is based on the thiyl radical-catalyzed cis-trans isomerization. The all-trans isomer of arachidonic acid was found to cause rabbit platelet aggregation at concentrations higher than 0.1 mM and inhibition of PAF-induced platelet aggregation in a concentration dependent manner with an IC50 in the micromolar range.

Original languageEnglish
Pages (from-to)2766-2770
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
Publication statusPublished - Jun 2 2005
Externally publishedYes


  • Platelet aggregation
  • Radical isomerization
  • trans Lipids
  • trans PUFA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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