TY - JOUR
T1 - Synthesis of all-trans arachidonic acid and its effect on rabbit platelet aggregation
AU - Anagnostopoulos, Dimitris
AU - Chatgilialoglu, Chryssostomos
AU - Ferreri, Carla
AU - Samadi, Abdelouahid
AU - Siafaka-Kapadai, Athanassia
N1 - Funding Information:
This work was supported in part by the European Community’s Human Potential Program under contract HPRN-CT-2002-00184 [SULFRAD], by HPMF-CT-2001-01313 (Marie Curie individual fellowship to A. Samadi), and by the University of Athens Special Account for Research Grants (70/4/3351).
PY - 2005/6/2
Y1 - 2005/6/2
N2 - A simple and high-yielding method to convert natural all-cis PUFA derivatives to the corresponding all-trans geometrical isomers is described. The method is based on the thiyl radical-catalyzed cis-trans isomerization. The all-trans isomer of arachidonic acid was found to cause rabbit platelet aggregation at concentrations higher than 0.1 mM and inhibition of PAF-induced platelet aggregation in a concentration dependent manner with an IC50 in the micromolar range.
AB - A simple and high-yielding method to convert natural all-cis PUFA derivatives to the corresponding all-trans geometrical isomers is described. The method is based on the thiyl radical-catalyzed cis-trans isomerization. The all-trans isomer of arachidonic acid was found to cause rabbit platelet aggregation at concentrations higher than 0.1 mM and inhibition of PAF-induced platelet aggregation in a concentration dependent manner with an IC50 in the micromolar range.
KW - Platelet aggregation
KW - Radical isomerization
KW - trans Lipids
KW - trans PUFA
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U2 - 10.1016/j.bmcl.2005.03.109
DO - 10.1016/j.bmcl.2005.03.109
M3 - Article
C2 - 15876534
AN - SCOPUS:19544375788
SN - 0960-894X
VL - 15
SP - 2766
EP - 2770
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 11
ER -