Synthesis of C7-substituted estra-1,3,5(10),6-tetraen-3,17β-diols

Goreti Ribeiro Morais, Maria Cristina das Neves Oliveira, Thies Thiemann

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene-3,17β-diols.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalLetters in Organic Chemistry
Issue number3
Publication statusPublished - Mar 2006
Externally publishedYes


  • Conjugate addition
  • Estranes
  • Steroids
  • Thermal dehydration

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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