Synthesis of C7-substituted estra-1,3,5(10),6-tetraen-3,17β-diols

Goreti Ribeiro Morais; Maria Cristina das Neves Oliveira; Thies Thiemann

doi:10.2174/157017806775789796

Synthesis of C7-substituted estra-1,3,5(10),6-tetraen-3,17β-diols

Goreti Ribeiro Morais, Maria Cristina das Neves Oliveira, Thies Thiemann

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene-3,17β-diols.

Original language	English
Pages (from-to)	214-219
Number of pages	6
Journal	Letters in Organic Chemistry
Volume	3
Issue number	3
DOIs	https://doi.org/10.2174/157017806775789796
Publication status	Published - Mar 2006
Externally published	Yes

Keywords

Conjugate addition
Estranes
Steroids
Thermal dehydration

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.2174/157017806775789796

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title = "Synthesis of C7-substituted estra-1,3,5(10),6-tetraen-3,17β-diols",

abstract = "A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene-3,17β-diols.",

keywords = "Conjugate addition, Estranes, Steroids, Thermal dehydration",

author = "Morais, {Goreti Ribeiro} and {das Neves Oliveira}, {Maria Cristina} and Thies Thiemann",

year = "2006",

month = mar,

doi = "10.2174/157017806775789796",

language = "English",

volume = "3",

pages = "214--219",

journal = "Letters in Organic Chemistry",

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T1 - Synthesis of C7-substituted estra-1,3,5(10),6-tetraen-3,17β-diols

AU - Morais, Goreti Ribeiro

AU - das Neves Oliveira, Maria Cristina

AU - Thiemann, Thies

PY - 2006/3

Y1 - 2006/3

N2 - A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene-3,17β-diols.

AB - A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene-3,17β-diols.

KW - Conjugate addition

KW - Estranes

KW - Steroids

KW - Thermal dehydration

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JF - Letters in Organic Chemistry

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ER -

Synthesis of C7-substituted estra-1,3,5(10),6-tetraen-3,17β-diols

Abstract

Keywords

ASJC Scopus subject areas

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