Abstract
The synthesis of a number of structurally related estradiol-17α- ylmethyl hydroxycinnamides and of one novel estra- 1,3,5(10),6-tetraen-3-ol- 17β-yl hydroxycinnamide is described, using a microwave assisted amidation of steroidal amines with pentafluorophenol activated, non-protected hydroxycinnamic acids as a key step. A selection of the compounds and of other estra-1,3,5(10)-trien-3-ol 17β-yl hydroxycinnamides was screened against 60 human cancer cell lines, derived from nine neoplastic diseases. From the overall results of the screening, it could be inferred that dihydroxycinnamide derived estradiol conjugates exhibit a better cytotoxic profile when compared with hydroxymethoxycinnamide derived estradiol conjugates.
Original language | English |
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Pages (from-to) | 549-554 |
Number of pages | 6 |
Journal | Journal of Chemical Research |
Volume | 36 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2012 |
Keywords
- Antiproliferative effect
- Cinnamides
- Cytotoxicity
- Estradiols
- Steroids
ASJC Scopus subject areas
- Chemistry(all)