Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies

Muhammad Nawaz, Muhammad Waseem Abbasi, Marium Tariq, John Patrick Graham, Abdul Rahman Saleh Al-Hagri, Ahmed Awad Elkarim, Muayad Elsiddig Mohamed, Veeranoot Nissapatorn, Muhammad Taha, Soleiman Hisaindee

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals to form complexes with applications as antipathogens, photoluminescent materials, corrosion inhibitors, and catalysts. Results: Anthranilic acid complexes (1–10) of Zn(II), Bi(III), Ag(I), Fe(II), Co(II), Cu(II), Mn(II), Al, Ni(II), and Cr(III) were synthesized and characterized using thermogravimetric (TGA), elemental analysis, FT-IR, UV–vis spectrometry, mass spectrometry and magnetic susceptibility. The morphology and size of metal complex (1–10) particles were determined by scanning electron microscope (SEM) and the surface area was determined by BET analysis. TGA and CHN analysis data indicated that the stoichiometries of complexes were 1:2 metal/ligand except for Ag(I), Al and Bi. Furthermore, DFT study was performed to optimize the structure of selected complexes. The complexes (1–10) were evaluated for their catalytic activity in the reduction of 4-nitrophenol (4-NP), antibacterial activity against S. aureus, P. aeroginosa and E. coli as well as their antifungal activity against F. solani and A. niger. The complexes were also tested against the second-stage juveniles (J2) root-knot nematodes. Conclusion: Co(II) complex 5 and Cu(II) complex 6 showed high catalytic activity for the reduction of 4-NP to 4-aminophenol (4-AP). Ag(I) complex 3 showed the best activity against the pathogens that were tested namely clinically important bacteria S. aureus, P. aeroginosa and E. coli, commercially important fungi F. solani and A. niger and J2 root-knot nematodes M. javanica.

Original languageEnglish
Article number21
JournalBMC Chemistry
Issue number1
Publication statusPublished - Dec 2022


  • Anthranilic acid
  • Biological activities
  • Catalysis
  • DFT
  • Environmental pollutants
  • Metal complexes

ASJC Scopus subject areas

  • General Chemistry


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