Synthesis of some novel oxazolopyranoquinolinones from 3-amino-4-hydroxypyrano[3,2-c]quinolinedione

Hany M. Hassanin; Ibrahim M. Abdou; Abdeltawab M. Saeed

doi:10.24820/ark.5550190.p010.196

Synthesis of some novel oxazolopyranoquinolinones from 3-amino-4-hydroxypyrano[3,2-c]quinolinedione

Hany M. Hassanin, Ibrahim M. Abdou, Abdeltawab M. Saeed

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

6-n-Butyl-3-nitropyrano[3,2-c]quinolinone was chemoselectively reduced to an amine derivative in a good yield (70%) using an efficient and simple tin-hydrochloric acid reaction. The novel 3-aminopyranoquinolinone was utilized as a precursor to produce some new interesting tetracyclic fused oxazolopyranoquinolinone analogues. The structures of the obtained quinolinone derivatives were confirmed using IR, LC-MS, ESI-MS and NMR techniques.

Original language	English
Pages (from-to)	335-349
Number of pages	15
Journal	Arkivoc
Volume	2017
Issue number	3
DOIs	https://doi.org/10.24820/ark.5550190.p010.196
Publication status	Published - Oct 8 2017

Keywords

Heterocyclization
Oxazole
Pyran
Quinolinone
Tin reduction

ASJC Scopus subject areas

Organic Chemistry

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10.24820/ark.5550190.p010.196

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title = "Synthesis of some novel oxazolopyranoquinolinones from 3-amino-4-hydroxypyrano[3,2-c]quinolinedione",

abstract = "6-n-Butyl-3-nitropyrano[3,2-c]quinolinone was chemoselectively reduced to an amine derivative in a good yield (70%) using an efficient and simple tin-hydrochloric acid reaction. The novel 3-aminopyranoquinolinone was utilized as a precursor to produce some new interesting tetracyclic fused oxazolopyranoquinolinone analogues. The structures of the obtained quinolinone derivatives were confirmed using IR, LC-MS, ESI-MS and NMR techniques.",

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AU - Hassanin, Hany M.

AU - Abdou, Ibrahim M.

AU - Saeed, Abdeltawab M.

N1 - Publisher Copyright: © ARKAT USA, Inc.

PY - 2017/10/8

Y1 - 2017/10/8

N2 - 6-n-Butyl-3-nitropyrano[3,2-c]quinolinone was chemoselectively reduced to an amine derivative in a good yield (70%) using an efficient and simple tin-hydrochloric acid reaction. The novel 3-aminopyranoquinolinone was utilized as a precursor to produce some new interesting tetracyclic fused oxazolopyranoquinolinone analogues. The structures of the obtained quinolinone derivatives were confirmed using IR, LC-MS, ESI-MS and NMR techniques.

AB - 6-n-Butyl-3-nitropyrano[3,2-c]quinolinone was chemoselectively reduced to an amine derivative in a good yield (70%) using an efficient and simple tin-hydrochloric acid reaction. The novel 3-aminopyranoquinolinone was utilized as a precursor to produce some new interesting tetracyclic fused oxazolopyranoquinolinone analogues. The structures of the obtained quinolinone derivatives were confirmed using IR, LC-MS, ESI-MS and NMR techniques.

KW - Heterocyclization

KW - Oxazole

KW - Pyran

KW - Quinolinone

KW - Tin reduction

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Synthesis of some novel oxazolopyranoquinolinones from 3-amino-4-hydroxypyrano[3,2-c]quinolinedione

Abstract

Keywords

ASJC Scopus subject areas

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