Synthesis of some novel oxazolopyranoquinolinones from 3-amino-4-hydroxypyrano[3,2-c]quinolinedione

Hany M. Hassanin, Ibrahim M. Abdou, Abdeltawab M. Saeed

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


6-n-Butyl-3-nitropyrano[3,2-c]quinolinone was chemoselectively reduced to an amine derivative in a good yield (70%) using an efficient and simple tin-hydrochloric acid reaction. The novel 3-aminopyranoquinolinone was utilized as a precursor to produce some new interesting tetracyclic fused oxazolopyranoquinolinone analogues. The structures of the obtained quinolinone derivatives were confirmed using IR, LC-MS, ESI-MS and NMR techniques.

Original languageEnglish
Pages (from-to)335-349
Number of pages15
Issue number3
Publication statusPublished - Oct 8 2017


  • Heterocyclization
  • Oxazole
  • Pyran
  • Quinolinone
  • Tin reduction

ASJC Scopus subject areas

  • Organic Chemistry


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