TY - JOUR
T1 - Targeting endoplasmic reticulum stress using natural products in neurological disorders
AU - Jangra, Ashok
AU - Verma, Mehak
AU - Kumar, Deepak
AU - Chandrika,
AU - Rachamalla, Mahesh
AU - Dey, Abhijit
AU - Dua, Kamal
AU - Jha, Saurabh Kumar
AU - Ojha, Shreesh
AU - Alexiou, Athanasios
AU - Kumar, Dinesh
AU - Jha, Niraj Kumar
N1 - Funding Information:
The authors would like to thank their respective institutes for their support. We would like to thank Editage (www.editage.com) for English language editing and BioRender (BioRender.com) for desigining figures incorporated in the manuscript.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/10
Y1 - 2022/10
N2 - The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.
AB - The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.
KW - Alzheimer's disease
KW - Endoplasmic reticulum stress
KW - Natural products
KW - Neurodegenerative diseases
KW - Neurological disorders
KW - Neuroprotection
KW - Neuroprotective agents
KW - Parkinson's disease
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U2 - 10.1016/j.neubiorev.2022.104818
DO - 10.1016/j.neubiorev.2022.104818
M3 - Comment/debate
C2 - 35940309
AN - SCOPUS:85136083592
SN - 0149-7634
VL - 141
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 104818
ER -