Targeting endoplasmic reticulum stress using natural products in neurological disorders

Ashok Jangra, Mehak Verma, Deepak Kumar, Chandrika, Mahesh Rachamalla, Abhijit Dey, Kamal Dua, Saurabh Kumar Jha, Shreesh Ojha, Athanasios Alexiou, Dinesh Kumar, Niraj Kumar Jha

Research output: Contribution to journalComment/debatepeer-review

4 Citations (Scopus)

Abstract

The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.

Original languageEnglish
Article number104818
JournalNeuroscience and Biobehavioral Reviews
Volume141
DOIs
Publication statusPublished - Oct 2022

Keywords

  • Alzheimer's disease
  • Endoplasmic reticulum stress
  • Natural products
  • Neurodegenerative diseases
  • Neurological disorders
  • Neuroprotection
  • Neuroprotective agents
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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