Targeting endoplasmic reticulum stress using natural products in neurological disorders

Ashok Jangra; Mehak Verma; Deepak Kumar; Chandrika; Mahesh Rachamalla; Abhijit Dey; Kamal Dua; Saurabh Kumar Jha; Shreesh Ojha; Athanasios Alexiou; Dinesh Kumar; Niraj Kumar Jha

doi:10.1016/j.neubiorev.2022.104818

Targeting endoplasmic reticulum stress using natural products in neurological disorders

Ashok Jangra
, Mehak Verma
, Deepak Kumar
, Chandrika
, Mahesh Rachamalla
, Abhijit Dey
, Kamal Dua
, Saurabh Kumar Jha
, Shreesh Ojha
, Athanasios Alexiou
, Dinesh Kumar
, Niraj Kumar Jha

Department of Pharmacology and Therapeutics

Research output: Contribution to journal › Comment/debate › peer-review

16 Citations (Scopus)

Abstract

The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.

Original language	English
Article number	104818
Journal	Neuroscience and Biobehavioral Reviews
Volume	141
DOIs	https://doi.org/10.1016/j.neubiorev.2022.104818
Publication status	Published - Oct 2022

Keywords

Alzheimer's disease
Endoplasmic reticulum stress
Natural products
Neurodegenerative diseases
Neurological disorders
Neuroprotection
Neuroprotective agents
Parkinson's disease

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/j.neubiorev.2022.104818

Cite this

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title = "Targeting endoplasmic reticulum stress using natural products in neurological disorders",

abstract = "The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.",

keywords = "Alzheimer's disease, Endoplasmic reticulum stress, Natural products, Neurodegenerative diseases, Neurological disorders, Neuroprotection, Neuroprotective agents, Parkinson's disease",

author = "Ashok Jangra and Mehak Verma and Deepak Kumar and Chandrika and Mahesh Rachamalla and Abhijit Dey and Kamal Dua and Jha, \{Saurabh Kumar\} and Shreesh Ojha and Athanasios Alexiou and Dinesh Kumar and Jha, \{Niraj Kumar\}",

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doi = "10.1016/j.neubiorev.2022.104818",

language = "English",

volume = "141",

journal = "Neuroscience and Biobehavioral Reviews",

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T1 - Targeting endoplasmic reticulum stress using natural products in neurological disorders

AU - Jangra, Ashok

AU - Verma, Mehak

AU - Kumar, Deepak

AU - Chandrika,

AU - Rachamalla, Mahesh

AU - Dey, Abhijit

AU - Dua, Kamal

AU - Jha, Saurabh Kumar

AU - Ojha, Shreesh

AU - Alexiou, Athanasios

AU - Kumar, Dinesh

AU - Jha, Niraj Kumar

PY - 2022/10

Y1 - 2022/10

N2 - The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.

AB - The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.

KW - Alzheimer's disease

KW - Endoplasmic reticulum stress

KW - Natural products

KW - Neurodegenerative diseases

KW - Neurological disorders

KW - Neuroprotection

KW - Neuroprotective agents

KW - Parkinson's disease

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UR - https://www.scopus.com/pages/publications/85136083592#tab=citedBy

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DO - 10.1016/j.neubiorev.2022.104818

M3 - Comment/debate

C2 - 35940309

AN - SCOPUS:85136083592

SN - 0149-7634

VL - 141

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

M1 - 104818

ER -

Targeting endoplasmic reticulum stress using natural products in neurological disorders

Abstract

Keywords

ASJC Scopus subject areas

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