TH-17 cell-related cytokines' potential role in the pathogenesis of severe asthma

Wisam Al-Ramli, Mohamed Al Samri, Qutayba Hamid

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Severe asthma represents a distinct, poorly-understood phenotype of asthma that has higher morbidity, mortality and a disproportionate need for health care support. Studies have indicated the presence of a specific inflammatory response in severe asthmatics, including the paucity of expression of classical Th-2 type cytokines. Following antigenic stimulation, naive CD4+ T cells proliferate and differentiate into various effector subsets such as Th-1 and Th-2 cells. A third subset of CD4+ T cells has recently been identified and designated as Th-17 cells, which produce IL-17A and F, IL-6, and TNF-α. In severe asthma, there may be a predominant Th-17 phenotype. These cells may promote the release of neutrophil chemotactic factors and induce the expression of GR-β, which is responsible for corticosteroid hyporesponsiveness in immune and structural cells. If the role of Th-17 cytokines is confirmed, it might provide a new option in controlling this refractory subtype of asthma.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalJournal of Asthma
Issue numberSUPPL. 1
Publication statusPublished - 2008


  • Cytokines
  • Inflammation
  • Neutrophil
  • Phenotype
  • Severe asthma
  • Th-17 cells

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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