TY - JOUR
T1 - The AGE-RAGE axis in an Arab population
T2 - The United Arab Emirates Healthy Futures (UAEHFS) pilot study
AU - Inman, Claire K.
AU - Aljunaibi, Abdullah
AU - Koh, Hyunwook
AU - Abdulle, Abdishakur
AU - Ali, Raghib
AU - Alnaeemi, Abdullah
AU - Al Zaabi, Eiman
AU - Oumeziane, Naima
AU - Al Bastaki, Marina
AU - Al-Houqani, Mohammed
AU - Al-Maskari, Fatma
AU - Al Dhaheri, Ayesha
AU - Shah, Syed M.
AU - Abdel Wareth, Laila
AU - Al Mahmeed, Wael
AU - Alsafar, Habiba
AU - Al Anouti, Fatme
AU - Al Hosani, Ayesha
AU - Haji, Muna
AU - Galani, Divya
AU - O'Connor, Matthew J.
AU - Ahn, Jiyoung
AU - Kirchhoff, Tomas
AU - Sherman, Scott
AU - Hayes, Richard B.
AU - Li, Huilin
AU - Ramasamy, Ravichandran
AU - Schmidt, Ann Marie
N1 - Funding Information:
The authors gratefully acknowledge the support of the funding organization New York University Abu Dhabi. The authors are grateful to Louise Ashall, Sneha Thomas, and Nosirudeen Quadri for their assistance in the AGE and CML-AGE assays and for the expert assistance of Ms. Latoya Woods in the preparation of this manuscript.
Publisher Copyright:
© 2017 The Authors
PY - 2017/12
Y1 - 2017/12
N2 - Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.
AB - Aims The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.
KW - Advanced glycation endproducts (AGEs)
KW - Cohort study
KW - Diabetes mellitus
KW - Obesity
KW - Receptor for AGE (RAGE)
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U2 - 10.1016/j.jcte.2017.08.001
DO - 10.1016/j.jcte.2017.08.001
M3 - Article
AN - SCOPUS:85029149166
SN - 2214-6237
VL - 10
SP - 1
EP - 8
JO - Journal of Clinical and Translational Endocrinology
JF - Journal of Clinical and Translational Endocrinology
ER -