The application of unsupervised clustering methods to Alzheimer’s disease

Hany Alashwal, Mohamed El Halaby, Jacob J. Crouse, Areeg Abdalla, Ahmed A. Moustafa

Research output: Contribution to journalReview articlepeer-review

108 Citations (Scopus)


Clustering is a powerful machine learning tool for detecting structures in datasets. In the medical field, clustering has been proven to be a powerful tool for discovering patterns and structure in labeled and unlabeled datasets. Unlike supervised methods, clustering is an unsupervised method that works on datasets in which there is no outcome (target) variable nor is anything known about the relationship between the observations, that is, unlabeled data. In this paper, we focus on studying and reviewing clustering methods that have been applied to datasets of neurological diseases, especially Alzheimer’s disease (AD). The aim is to provide insights into which clustering technique is more suitable for partitioning patients of AD based on their similarity. This is important as clustering algorithms can find patterns across patients that are difficult for medical practitioners to find. We further discuss the implications of the use of clustering algorithms in the treatment of AD. We found that clustering analysis can point to several features that underlie the conversion from early-stage AD to advanced AD. Furthermore, future work can apply semi-clustering algorithms on AD datasets, which will enhance clusters by including additional information.

Original languageEnglish
Article number31
JournalFrontiers in Computational Neuroscience
Publication statusPublished - May 24 2019


  • Alzheimer’s disease
  • Clustering
  • Machine learning techniques
  • Neurological diseases
  • Unsupervised learning

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience


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