TY - JOUR
T1 - The benefits of physical activity in middle-aged individuals for cardiovascular disease outcomes
AU - Shakoor, Hira
AU - Platat, Carine
AU - Ali, Habiba I.
AU - Ismail, Leila Cheikh
AU - Al Dhaheri, Ayesha Salem
AU - Bosevski, Marijan
AU - Apostolopoulos, Vasso
AU - Stojanovska, Lily
N1 - Funding Information:
H.S. C.P. H.I.A. L.C.I. A.S.AD. and L.S. would like to acknowledge the Department of Nutrition and Health, United Arab Emirates University for their ongoing support. V.A. would like to thank the Immunology and Translational Research Group and the Institute for Health and Sport, Victoria University for their support.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/2
Y1 - 2023/2
N2 - Regular physical activity (PA) has a positive role in preventing cardiovascular disease (CVD). Due to a trend toward a more sedentary lifestyle, the middle-aged population (35–65 years) is at greater risk of developing CVD. It is well established that PA improves cardiorespiratory fitness and reduces the risk of cardiovascular mortality and cardiovascular events, including stroke, coronary heart disease, heart failure, hypercholesterolemia, atherosclerosis, diabetes, and blood pressure. PA can potentially decrease oxidative stress and systemic inflammation, which are the two main underlying mechanisms leading to CVD. By reducing CRP, TNF-α, INF-γ, NF-κB and increasing IL-10, IL-4, and IL-8, PA can prevent the initiation and progression of CVD in middle-aged adults, highlighting the importance of being physically active for this age group. The general recommendation for PA to prevent CVD is at least 150 min/week at a moderate level of intensity; the type of PA should be adapted to the fitness level and medical condition of the individual. However, standardized guidelines for middle-aged individuals with cardiovascular events still need to be established.
AB - Regular physical activity (PA) has a positive role in preventing cardiovascular disease (CVD). Due to a trend toward a more sedentary lifestyle, the middle-aged population (35–65 years) is at greater risk of developing CVD. It is well established that PA improves cardiorespiratory fitness and reduces the risk of cardiovascular mortality and cardiovascular events, including stroke, coronary heart disease, heart failure, hypercholesterolemia, atherosclerosis, diabetes, and blood pressure. PA can potentially decrease oxidative stress and systemic inflammation, which are the two main underlying mechanisms leading to CVD. By reducing CRP, TNF-α, INF-γ, NF-κB and increasing IL-10, IL-4, and IL-8, PA can prevent the initiation and progression of CVD in middle-aged adults, highlighting the importance of being physically active for this age group. The general recommendation for PA to prevent CVD is at least 150 min/week at a moderate level of intensity; the type of PA should be adapted to the fitness level and medical condition of the individual. However, standardized guidelines for middle-aged individuals with cardiovascular events still need to be established.
KW - Cardiorespiratory fitness
KW - Cardiovascular disease
KW - Exercise
KW - Inflammation
KW - Oxidative stress
KW - Physical activity
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U2 - 10.1016/j.maturitas.2022.11.002
DO - 10.1016/j.maturitas.2022.11.002
M3 - Short survey
C2 - 36462307
AN - SCOPUS:85143544611
SN - 0378-5122
VL - 168
SP - 49
EP - 52
JO - Maturitas
JF - Maturitas
ER -