Klinische aussagekraft des tumormarkers CA 19-9 unter besonderer berücksichtigung des Lewis-phänotyps

Translated title of the contribution: The clinical relevance of the tumor marker CA 19-9 with special reference to the Lewis phenotype: Background

G. Kolb, F. Safi, K. Beckh, H. G. Beger

Research output: Contribution to journalArticlepeer-review

Abstract

Because of structure and biosynthesis of CA 19-9 it was postulated, that patients with the Lewis phenotype Le a-b- are not able to synthesize CA 19-9. But some patients with Le a-b- on red blood cells showed elevated levels of this tumor marker. Patients and method: In 164 patients suffering from benign or malignant diseases both CA 19-9 and the Lewis phenotype were determined in sera. In addition in 51 patients red blood cells were tested for Lewis substances. Results: The frequencies of the different Lewis phenotypes on red blood cells were compared with the results found in sera. The prevalence of the phenotype Le a-b- on erythrocytes was significantly higher than in sera. In 51 patients both determinations were performed. These results were compared additionally. The phenotype Le a-b- found on red blood cells agreed with the results found in sera only in 30% of the cases. A loss of Lewis substances on erythrocytes could be seen both in malignant and benign diseases. Only in patients with Lewis substances found in sera elevated levels of CA 19-9 could be seen. Conclusion: Considering only the Lewis phenotype in sera it could be confirmed, that patients with the genotype Le a-b- are not able to express elevated concentrations of CA 19-9.

Translated title of the contributionThe clinical relevance of the tumor marker CA 19-9 with special reference to the Lewis phenotype: Background
Original languageGerman
Pages (from-to)177-181
Number of pages5
JournalTumor Diagnostik und Therapie
Volume17
Issue number6
Publication statusPublished - Dec 1 1996

Keywords

  • 9
  • CA 19
  • Lewis-phenotype
  • Pancreatic carcinoma

ASJC Scopus subject areas

  • Oncology

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