The contribution of growth hormone to mammary neoplasia

Jo K. Perry; Kumarasamypet M. Mohankumar; B. Starling Emerald; Hichem C. Mertani; Peter E. Lobie

doi:10.1007/s10911-008-9070-z

The contribution of growth hormone to mammary neoplasia

Jo K. Perry, Kumarasamypet M. Mohankumar, B. Starling Emerald, Hichem C. Mertani, Peter E. Lobie

Research output: Contribution to journal › Review article › peer-review

70 Citations (Scopus)

Abstract

While the effects of growth hormone (GH) on longitudinal growth are well established, the observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in the development and progression of a wide range malignancies including breast cancer. Recently autocrine human GH been demonstrated to be an orthotopically expressed oncogene for the human mammary gland. This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer.

Original language	English
Pages (from-to)	131-145
Number of pages	15
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s10911-008-9070-z
Publication status	Published - Mar 2008
Externally published	Yes

Keywords

Breast cancer
Growth hormone
Mammary development

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10911-008-9070-z

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abstract = "While the effects of growth hormone (GH) on longitudinal growth are well established, the observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in the development and progression of a wide range malignancies including breast cancer. Recently autocrine human GH been demonstrated to be an orthotopically expressed oncogene for the human mammary gland. This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer.",

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AU - Mohankumar, Kumarasamypet M.

AU - Emerald, B. Starling

AU - Mertani, Hichem C.

AU - Lobie, Peter E.

N1 - Funding Information: Acknowledgment This work was supported by the Breast Cancer Research Trust of New Zealand (NZ), the Foundation of Research Science and Technology (NZ) and the Department of Defense, CDMRP (USA).

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N2 - While the effects of growth hormone (GH) on longitudinal growth are well established, the observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in the development and progression of a wide range malignancies including breast cancer. Recently autocrine human GH been demonstrated to be an orthotopically expressed oncogene for the human mammary gland. This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer.

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KW - Mammary development

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The contribution of growth hormone to mammary neoplasia

Abstract

Keywords

ASJC Scopus subject areas

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