The effect of acidosis on the ECG of the rat heart

A. Aberra; K. Komukai; F. C. Howarth; C. H. Orchard

doi:10.1113/eph8602051

The effect of acidosis on the ECG of the rat heart

A. Aberra, K. Komukai, F. C. Howarth, C. H. Orchard

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P-R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis-induced changes in transmitter release from severed autonomic nerve terminals within the heart.

Original language	English
Pages (from-to)	27-31
Number of pages	5
Journal	Experimental Physiology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1113/eph8602051
Publication status	Published - 2001

ASJC Scopus subject areas

Physiology
Nutrition and Dietetics
Physiology (medical)

Access to Document

10.1113/eph8602051

Cite this

@article{a4ff1474af644ff0b8c1fde9c21a84d8,

title = "The effect of acidosis on the ECG of the rat heart",

abstract = "We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P-R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis-induced changes in transmitter release from severed autonomic nerve terminals within the heart.",

author = "A. Aberra and K. Komukai and Howarth, {F. C.} and Orchard, {C. H.}",

year = "2001",

doi = "10.1113/eph8602051",

language = "English",

volume = "86",

pages = "27--31",

journal = "Experimental Physiology",

issn = "0958-0670",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - The effect of acidosis on the ECG of the rat heart

AU - Aberra, A.

AU - Komukai, K.

AU - Howarth, F. C.

AU - Orchard, C. H.

PY - 2001

Y1 - 2001

N2 - We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P-R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis-induced changes in transmitter release from severed autonomic nerve terminals within the heart.

AB - We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P-R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis-induced changes in transmitter release from severed autonomic nerve terminals within the heart.

UR - http://www.scopus.com/inward/record.url?scp=0035132407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035132407&partnerID=8YFLogxK

U2 - 10.1113/eph8602051

DO - 10.1113/eph8602051

M3 - Article

C2 - 11429616

AN - SCOPUS:0035132407

SN - 0958-0670

VL - 86

SP - 27

EP - 31

JO - Experimental Physiology

JF - Experimental Physiology

IS - 1

ER -

The effect of acidosis on the ECG of the rat heart

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this