The effect of acidosis on the ECG of the rat heart

A. Aberra, K. Komukai, F. C. Howarth, C. H. Orchard

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P-R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis-induced changes in transmitter release from severed autonomic nerve terminals within the heart.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalExperimental Physiology
Volume86
Issue number1
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'The effect of acidosis on the ECG of the rat heart'. Together they form a unique fingerprint.

Cite this