The effect of risperidone on cognition in patients with schizophrenia

Emmanuel Stip, Isabelle Lussier

Research output: Contribution to journalArticlepeer-review

112 Citations (Scopus)


Objective: To evaluate the effect of risperidone on cognitive functions after both 6 weeks and 6 months of treatment and to determine whether any improvement on neuropsychological function relates to improvement in psychopathology. Method: Patients' psychiatric and extrapyramidal symptoms were assessed while they were receiving classical neuroleptic treatment and adjunctive medications. Patients were then reassessed after changing to a new treatment of risperidone. Results: During treatment with risperidone, schizophrenic patients displayed improved performance mainly on attentional components, specifically, selective attention and alertness. Conclusion: In patients who were given risperidone, there was a positive correlation between improvement in psychopathology and improvement in cognitive tests of explicit memory and alertness.

Original languageEnglish
Pages (from-to)S35-S40
JournalCanadian Journal of Psychiatry
Issue number8 SUPPL. 2
Publication statusPublished - Oct 1996
Externally publishedYes


  • adverse effects
  • attention
  • atypical neuroleptics
  • cognition
  • memory
  • risperidone
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health


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