TY - JOUR
T1 - The effects of bariatric surgery on vitamin b status and mental health
AU - Mansoori, Amna Al
AU - Shakoor, Hira
AU - Ali, Habiba I.
AU - Feehan, Jack
AU - Al Dhaheri, Ayesha S.
AU - Ismail, Leila Cheikh
AU - Bosevski, Marijan
AU - Apostolopoulos, Vasso
AU - Stojanovska, Lily
N1 - Funding Information:
Acknowledgments: H.S., A.A.M., H.I.A., L.S., and A.S.A.D. would like to acknowledge the Department of Nutrition and Health, United Arab Emirates University for their ongoing support. L.C.I. thanks College of Health Sciences and RIMHS University of Sharjah for their support. J.F. would like to acknowledge the Australian Government for the support for an RTP training scholarship and University of Melbourne PhD Stipend. J.F. and V.A. would like to thank the Immunology and Translational Research Group within the Institute for Health and Sport, Victoria University Australia for their support.
Funding Information:
H.S., A.A.M., H.I.A., L.S., and A.S.A.D. would like to acknowledge the Department of Nutrition and Health, United Arab Emirates University for their ongoing support. L.C.I. thanks College of Health Sciences and RIMHS University of Sharjah for their support. J.F. would like to acknowledge the Australian Government for the support for an RTP training scholarship and University of Melbourne PhD Stipend. J.F. and V.A. would like to thank the Immunology and Translational Research Group within the Institute for Health and Sport, Victoria University Australia for their support.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/4
Y1 - 2021/4
N2 - Diet is a modifiable factor that ensures optimal growth, biochemical performance, improved mood and mental functioning. Lack of nutrients, notably vitamin B, has an impact on human health and wellbeing. The United Arab Emirates is facing a serious problem of micronutrient deficiencies because of the growing trend for bariatric surgery, including Roux-en-Y gastric bypass and sleeve gastrectomy. People undergoing bariatric surgery are at high risk of developing neurological, cognitive, and mental disabilities and cardiovascular disease due to deficiency in vitamin B. Vitamin B is involved in neurotransmitter synthesis, including γ-aminobutyric acid, serotonin, dopamine, and noradrenaline. Deficiency of vitamin B increases the risk of depression, anxiety, dementia and Alzheimer’s disease. In addition, vitamin B deficiency can disrupt the methylation of homocysteine, leading to hyperhomocysteinemia. Elevated homocysteine levels are detrimental to human health. Vitamin B deficiency also suppresses immune function, increases the production of pro-inflammatory cytokines and upregulates NF-κB. Considering the important functions of vitamin B and the severe consequences associated with its deficiency following bariatric surgery, proper dietary intervention and administration of adequate supplements should be considered to prevent negative clinical outcomes.
AB - Diet is a modifiable factor that ensures optimal growth, biochemical performance, improved mood and mental functioning. Lack of nutrients, notably vitamin B, has an impact on human health and wellbeing. The United Arab Emirates is facing a serious problem of micronutrient deficiencies because of the growing trend for bariatric surgery, including Roux-en-Y gastric bypass and sleeve gastrectomy. People undergoing bariatric surgery are at high risk of developing neurological, cognitive, and mental disabilities and cardiovascular disease due to deficiency in vitamin B. Vitamin B is involved in neurotransmitter synthesis, including γ-aminobutyric acid, serotonin, dopamine, and noradrenaline. Deficiency of vitamin B increases the risk of depression, anxiety, dementia and Alzheimer’s disease. In addition, vitamin B deficiency can disrupt the methylation of homocysteine, leading to hyperhomocysteinemia. Elevated homocysteine levels are detrimental to human health. Vitamin B deficiency also suppresses immune function, increases the production of pro-inflammatory cytokines and upregulates NF-κB. Considering the important functions of vitamin B and the severe consequences associated with its deficiency following bariatric surgery, proper dietary intervention and administration of adequate supplements should be considered to prevent negative clinical outcomes.
KW - Bariatric surgery
KW - Dopamine
KW - Homocysteine
KW - Pro-inflammatory cytokines
KW - Serotonin
KW - Vitamin B
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U2 - 10.3390/nu13041383
DO - 10.3390/nu13041383
M3 - Review article
C2 - 33923999
AN - SCOPUS:85104475710
SN - 2072-6643
VL - 13
JO - Nutrients
JF - Nutrients
IS - 4
M1 - 1383
ER -