The effects of vitamin B on the immune/cytokine network and their involvement in depression

Kathleen Mikkelsen; Lily Stojanovska; Monica Prakash; Vasso Apostolopoulos

doi:10.1016/j.maturitas.2016.11.012

The effects of vitamin B on the immune/cytokine network and their involvement in depression

Kathleen Mikkelsen, Lily Stojanovska, Monica Prakash, Vasso Apostolopoulos

Research output: Contribution to journal › Review article › peer-review

77 Citations (Scopus)

Abstract

Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.

Original language	English
Pages (from-to)	58-71
Number of pages	14
Journal	Maturitas
Volume	96
DOIs	https://doi.org/10.1016/j.maturitas.2016.11.012
Publication status	Published - Feb 1 2017
Externally published	Yes

Keywords

Depression
Immune cells
Immune system
Inflammation
Mental health

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Obstetrics and Gynaecology

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10.1016/j.maturitas.2016.11.012

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title = "The effects of vitamin B on the immune/cytokine network and their involvement in depression",

abstract = "Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.",

keywords = "Depression, Immune cells, Immune system, Inflammation, Mental health",

author = "Kathleen Mikkelsen and Lily Stojanovska and Monica Prakash and Vasso Apostolopoulos",

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T1 - The effects of vitamin B on the immune/cytokine network and their involvement in depression

AU - Mikkelsen, Kathleen

AU - Stojanovska, Lily

AU - Prakash, Monica

AU - Apostolopoulos, Vasso

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.

AB - Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.

KW - Depression

KW - Immune cells

KW - Immune system

KW - Inflammation

KW - Mental health

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DO - 10.1016/j.maturitas.2016.11.012

M3 - Review article

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SN - 0378-5122

VL - 96

SP - 58

EP - 71

JO - Maturitas

JF - Maturitas

ER -

The effects of vitamin B on the immune/cytokine network and their involvement in depression

Abstract

Keywords

ASJC Scopus subject areas

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