The endoplasmic reticulum and mitochondria as elements of the mechanism of intracellular signaling in the nerve cell

P. G. Kostyuk; A. V. Shmigol'; N. V. Voitenko; N. V. Svichar; E. P. Kostyuk

doi:10.1007/BF02461387

The endoplasmic reticulum and mitochondria as elements of the mechanism of intracellular signaling in the nerve cell

P. G. Kostyuk, A. V. Shmigol', N. V. Voitenko, N. V. Svichar, E. P. Kostyuk

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Experimental data obtained in our laboratory from studies of intracellular signals arising within nerve cells during excitation are summarized. Measurements of transmembrane ion currents in conditions of fixed membrane potential and intracellular free Ca ion concentrations, using fluorescent probes, yielded the time and spatial characteristics of transient elevations in the Ca concentration (the 'calcium signal') in various types of mouse and rat neurons. These studies showed that intracellular structures - the endoplasmic reticulum and mitochondria - had significant roles in forming these signals; these structures can take up Ca from the cytosol and liberate Ca into the cytosol; the contribution of these processes was extremely variable, depending on the internal organization of different functional types of neurons.

Original language	English
Pages (from-to)	15-18
Number of pages	4
Journal	Neuroscience and Behavioral Physiology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1007/BF02461387
Publication status	Published - 2000
Externally published	Yes

Keywords

Ca ions
Endoplasmic reticulum
Excitation
Nerve cell

ASJC Scopus subject areas

Neuroscience(all)

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10.1007/BF02461387

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abstract = "Experimental data obtained in our laboratory from studies of intracellular signals arising within nerve cells during excitation are summarized. Measurements of transmembrane ion currents in conditions of fixed membrane potential and intracellular free Ca ion concentrations, using fluorescent probes, yielded the time and spatial characteristics of transient elevations in the Ca concentration (the 'calcium signal') in various types of mouse and rat neurons. These studies showed that intracellular structures - the endoplasmic reticulum and mitochondria - had significant roles in forming these signals; these structures can take up Ca from the cytosol and liberate Ca into the cytosol; the contribution of these processes was extremely variable, depending on the internal organization of different functional types of neurons.",

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T1 - The endoplasmic reticulum and mitochondria as elements of the mechanism of intracellular signaling in the nerve cell

AU - Kostyuk, P. G.

AU - Shmigol', A. V.

AU - Voitenko, N. V.

AU - Svichar, N. V.

AU - Kostyuk, E. P.

PY - 2000

Y1 - 2000

N2 - Experimental data obtained in our laboratory from studies of intracellular signals arising within nerve cells during excitation are summarized. Measurements of transmembrane ion currents in conditions of fixed membrane potential and intracellular free Ca ion concentrations, using fluorescent probes, yielded the time and spatial characteristics of transient elevations in the Ca concentration (the 'calcium signal') in various types of mouse and rat neurons. These studies showed that intracellular structures - the endoplasmic reticulum and mitochondria - had significant roles in forming these signals; these structures can take up Ca from the cytosol and liberate Ca into the cytosol; the contribution of these processes was extremely variable, depending on the internal organization of different functional types of neurons.

AB - Experimental data obtained in our laboratory from studies of intracellular signals arising within nerve cells during excitation are summarized. Measurements of transmembrane ion currents in conditions of fixed membrane potential and intracellular free Ca ion concentrations, using fluorescent probes, yielded the time and spatial characteristics of transient elevations in the Ca concentration (the 'calcium signal') in various types of mouse and rat neurons. These studies showed that intracellular structures - the endoplasmic reticulum and mitochondria - had significant roles in forming these signals; these structures can take up Ca from the cytosol and liberate Ca into the cytosol; the contribution of these processes was extremely variable, depending on the internal organization of different functional types of neurons.

KW - Ca ions

KW - Endoplasmic reticulum

KW - Excitation

KW - Nerve cell

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The endoplasmic reticulum and mitochondria as elements of the mechanism of intracellular signaling in the nerve cell

Abstract

Keywords

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