TY - JOUR
T1 - The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group
AU - Brunham, Robert C.
AU - Kimani, Joshua
AU - Bwayo, Job
AU - Maitha, Gregory
AU - Maclean, Ian
AU - Yang, Chunlin
AU - Shen, Caixia
AU - Roman, Susan
AU - Nagelkerke, Nico J.D.
AU - Cheang, Mary
AU - Plummer, Francis A.
N1 - Funding Information:
Received 12 September 1995; revised 22 November 1995. Informed consent was obtained from all study participants at their enrollment visit after review of the protocol by the Institutional Review Boards of the University of Nairobi and the University of Manitoba. Grant support: Medical Research Council of Canada (SP27); Nationallnstitutes of Health (955920). Reprints or correspondence: Dr. Robert C. Brunham, Dept. ofMedical Microbiology, University of Manitoba, Room 543,730 William Ave., Winnipeg, Manitoba, R3E OW3, Canada.
PY - 1996
Y1 - 1996
N2 - Female sex workers in Nairobi were prospectively evaluated for risk factors of incident Chlamydia trachomatis infection. Independent risk factors included cervical ectopy (P = .007), gonococcal infection (P = .002), human immunodeficiency virus (HIV) seropositivity (P = .003), HIV seroconversion (P = .001), and duration of prostitution (P = .002). Eighteen different C. trachomatis outer membrane protein (omp1) genotypes were identified, with the allelic composition of the C. trachomatis population changing significantly over time (P = .005). Seventeen of 19 reinfections >6 months apart were with different C. trachomatis omp1 genotypes. Women with HIV infection had an increased proportion of visits with C. trachomatis infection (P = .001) and an increased risk of reinfection (P = .008). Overall, the data demonstrate significant fluctuations in the genotype composition of the C. trachomatis population and a reduced rate of same-genotype reinfection consistent with the occurrence of strain-specific immunity.
AB - Female sex workers in Nairobi were prospectively evaluated for risk factors of incident Chlamydia trachomatis infection. Independent risk factors included cervical ectopy (P = .007), gonococcal infection (P = .002), human immunodeficiency virus (HIV) seropositivity (P = .003), HIV seroconversion (P = .001), and duration of prostitution (P = .002). Eighteen different C. trachomatis outer membrane protein (omp1) genotypes were identified, with the allelic composition of the C. trachomatis population changing significantly over time (P = .005). Seventeen of 19 reinfections >6 months apart were with different C. trachomatis omp1 genotypes. Women with HIV infection had an increased proportion of visits with C. trachomatis infection (P = .001) and an increased risk of reinfection (P = .008). Overall, the data demonstrate significant fluctuations in the genotype composition of the C. trachomatis population and a reduced rate of same-genotype reinfection consistent with the occurrence of strain-specific immunity.
UR - https://www.scopus.com/pages/publications/19144364377
UR - https://www.scopus.com/pages/publications/19144364377#tab=citedBy
U2 - 10.1093/infdis/173.4.950
DO - 10.1093/infdis/173.4.950
M3 - Article
C2 - 8603976
AN - SCOPUS:19144364377
SN - 0022-1899
VL - 173
SP - 950
EP - 956
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -