The exceptional glutathione peroxidase-like activity of di(3-hydroxypropyl) selenide and the unexpected role of a novel spirodioxaselenanonane intermediate in the catalytic cycle

Thomas G. Back; Ziad Moussa; Masood Parvez

doi:10.1002/anie.200353128

The exceptional glutathione peroxidase-like activity of di(3-hydroxypropyl) selenide and the unexpected role of a novel spirodioxaselenanonane intermediate in the catalytic cycle

Thomas G. Back, Ziad Moussa, Masood Parvez

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Abstract

A new mechanism for reducing oxidative stress: Di(3-hydroxypropyl) selenide has exceptionally high glutathione peroxidase-like catalytic activity in the reduction of tert-butyl hydroperoxide with benzyl thiol. The catalytic cycle proceeds via a novel spirodioxaselenanonane, which was isolated and characterized spectroscopically, as well as by X-ray crystallography.

Original language	English
Pages (from-to)	1268-1270
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	10
DOIs	https://doi.org/10.1002/anie.200353128
Publication status	Published - Feb 27 2004
Externally published	Yes

Keywords

Oxidative stress
Peroxidases
Selenium
Spiro compounds
Thiols

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200353128

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The exceptional glutathione peroxidase-like activity of di(3-hydroxypropyl) selenide and the unexpected role of a novel spirodioxaselenanonane intermediate in the catalytic cycle. / Back, Thomas G.; Moussa, Ziad; Parvez, Masood.
In: Angewandte Chemie - International Edition, Vol. 43, No. 10, 27.02.2004, p. 1268-1270.

Research output: Contribution to journal › Article › peer-review

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The exceptional glutathione peroxidase-like activity of di(3-hydroxypropyl) selenide and the unexpected role of a novel spirodioxaselenanonane intermediate in the catalytic cycle

Abstract

Keywords

ASJC Scopus subject areas

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