The exceptional glutathione peroxidase-like activity of di(3-hydroxypropyl) selenide and the unexpected role of a novel spirodioxaselenanonane intermediate in the catalytic cycle

Thomas G. Back, Ziad Moussa, Masood Parvez

Research output: Contribution to journalArticlepeer-review

126 Citations (Scopus)

Abstract

A new mechanism for reducing oxidative stress: Di(3-hydroxypropyl) selenide has exceptionally high glutathione peroxidase-like catalytic activity in the reduction of tert-butyl hydroperoxide with benzyl thiol. The catalytic cycle proceeds via a novel spirodioxaselenanonane, which was isolated and characterized spectroscopically, as well as by X-ray crystallography.

Original languageEnglish
Pages (from-to)1268-1270
Number of pages3
JournalAngewandte Chemie - International Edition
Volume43
Issue number10
DOIs
Publication statusPublished - Feb 27 2004
Externally publishedYes

Keywords

  • Oxidative stress
  • Peroxidases
  • Selenium
  • Spiro compounds
  • Thiols

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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