Abstract
A new mechanism for reducing oxidative stress: Di(3-hydroxypropyl) selenide has exceptionally high glutathione peroxidase-like catalytic activity in the reduction of tert-butyl hydroperoxide with benzyl thiol. The catalytic cycle proceeds via a novel spirodioxaselenanonane, which was isolated and characterized spectroscopically, as well as by X-ray crystallography.
| Original language | English |
|---|---|
| Pages (from-to) | 1268-1270 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 43 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Feb 27 2004 |
| Externally published | Yes |
Keywords
- Oxidative stress
- Peroxidases
- Selenium
- Spiro compounds
- Thiols
ASJC Scopus subject areas
- Catalysis
- General Chemistry
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