The farnesyltransferase inhibitor manumycin A is a novel trypanocide with a complex mode of action including major effects on mitochondria

Agriculture & Biology

• bloodstream forms 39%
• cell cycle 24%
• cell death 25%
• cell growth 23%
• cells 8%
• crossover interference 28%
• DNA 14%
• electrons 20%
• eukaryotic cells 47%
• geranylgeranyl diphosphate synthase 81%
• guanosinetriphosphatase 31%
• isoprene 36%
• lethal genes 27%
• mechanism of action 47%
• mice 16%
• mitochondria 42%
• neoplasms 21%
• polypeptides 21%
• procyclic forms 43%
• protein synthesis 20%
• proteins 9%
• protons 26%
• pyrophosphates 31%
• quinones 28%
• synthesis 15%
• trypanocides 84%
• Trypanosoma brucei 68%
• trypanosomiasis 34%

Medicine & Life Sciences

• Cell Cycle 5%
• Cell Death 5%
• diphosphoric acid 9%
• DNA 3%
• Electron Transport 7%
• Eukaryota 14%
• Farnesyltranstransferase 84%
• Growth 6%
• In Vitro Techniques 3%
• isoprene 11%
• manumycin 100%
• Membranes 4%
• Mevalonic Acid 9%
• Mitochondria 45%
• Monomeric GTP-Binding Proteins 8%
• Neoplasms 2%
• Peptides 4%
• prenyl 22%
• Prenylation 19%
• Proteins 5%
• Protons 7%
• quinone 8%
• Serum 3%
• Trypanocidal Agents 91%
• Trypanosoma brucei brucei 18%
• Trypanosomiasis 10%