TY - JOUR
T1 - The HLA A2/6802 supertype is associated with reduced risk of perinatal human immunodeficiency virus type 1 transmission
AU - MacDonald, Kelly S.
AU - Embree, Joanne E.
AU - Nagelkerke, Nico J.D.
AU - Castillo, Jose
AU - Ramhadin, Susie
AU - Njenga, Simon
AU - Oyug, Julius
AU - Ndinya-Achola, Jekoniah
AU - Barber, Brian H.
AU - Bwayo, Job J.
AU - Plummer, Francis A.
N1 - Funding Information:
Financial support: Canadian Institutes of Health Research (CIHR; grant GR-13301). K.S.M. is an Ontario HIV Treatment Network career scientist. F.A.P. is a CIHR senior scientist.
PY - 2001/2/1
Y1 - 2001/2/1
N2 - Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV-1 among sex workers. The alleles in this supertype present the same HIV-1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLA A2/6802 supertype influenced HIV-1 transmission in a prospective cohort of HIV-1-infected mothers and children in Kenya. Decreased perinatal HIV-1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03-0.54; P = .006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission.
AB - Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV-1 among sex workers. The alleles in this supertype present the same HIV-1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLA A2/6802 supertype influenced HIV-1 transmission in a prospective cohort of HIV-1-infected mothers and children in Kenya. Decreased perinatal HIV-1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03-0.54; P = .006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission.
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U2 - 10.1086/318092
DO - 10.1086/318092
M3 - Article
C2 - 11133384
AN - SCOPUS:0035253455
SN - 0022-1899
VL - 183
SP - 503
EP - 506
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -