The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man

T. E. Adrian; H. S. Besterman; S. R. Bloom

doi:10.1016/0024-3205(79)90310-2

The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man

T. E. Adrian, H. S. Besterman, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.

Original language	English
Pages (from-to)	1989-1993
Number of pages	5
Journal	Life Sciences
Volume	24
Issue number	21
DOIs	https://doi.org/10.1016/0024-3205(79)90310-2
Publication status	Published - May 21 1979
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(79)90310-2

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title = "The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man",

abstract = "The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.",

author = "Adrian, {T. E.} and Besterman, {H. S.} and Bloom, {S. R.}",

note = "Funding Information: Purified human pancreatic polypaptide and specific antiaera were generous gifts from Dr R E Chance (Lilly Research Laboratories, Indianapolis) . Generous support was received from The Wellcome Trust and the British Diabetic Association .",

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AU - Adrian, T. E.

AU - Besterman, H. S.

AU - Bloom, S. R.

N1 - Funding Information: Purified human pancreatic polypaptide and specific antiaera were generous gifts from Dr R E Chance (Lilly Research Laboratories, Indianapolis) . Generous support was received from The Wellcome Trust and the British Diabetic Association .

PY - 1979/5/21

Y1 - 1979/5/21

N2 - The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.

AB - The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.

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SP - 1989

EP - 1993

JO - Life Sciences

JF - Life Sciences

IS - 21

ER -

The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man

Abstract

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