The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man

T. E. Adrian; H. S. Besterman; S. R. Bloom

doi:10.1016/0024-3205(79)90310-2

The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man

T. E. Adrian
, H. S. Besterman
, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.

Original language	English
Pages (from-to)	1989-1993
Number of pages	5
Journal	Life Sciences
Volume	24
Issue number	21
DOIs	https://doi.org/10.1016/0024-3205(79)90310-2
Publication status	Published - May 21 1979
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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10.1016/0024-3205(79)90310-2

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title = "The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man",

abstract = "The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7\% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.",

author = "Adrian, \{T. E.\} and Besterman, \{H. S.\} and Bloom, \{S. R.\}",

note = "Funding Information: Purified human pancreatic polypaptide and specific antiaera were generous gifts from Dr R E Chance (Lilly Research Laboratories, Indianapolis) . Generous support was received from The Wellcome Trust and the British Diabetic Association .",

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AU - Adrian, T. E.

AU - Besterman, H. S.

AU - Bloom, S. R.

N1 - Funding Information: Purified human pancreatic polypaptide and specific antiaera were generous gifts from Dr R E Chance (Lilly Research Laboratories, Indianapolis) . Generous support was received from The Wellcome Trust and the British Diabetic Association .

PY - 1979/5/21

Y1 - 1979/5/21

N2 - The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.

AB - The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.

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U2 - 10.1016/0024-3205(79)90310-2

DO - 10.1016/0024-3205(79)90310-2

M3 - Article

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VL - 24

SP - 1989

EP - 1993

JO - Life Sciences

JF - Life Sciences

IS - 21

ER -

The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man

Abstract

ASJC Scopus subject areas

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