The mechanisms tumor cells utilize to evade the host's immune system

Nyanbol Kuol, Lily Stojanovska, Kulmira Nurgali, Vasso Apostolopoulos

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)

Abstract

The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD-L1, IDO and siglec-9. In addition, tumor cells not only regulate the recruitment and development of immunosuppressive forces to influence the tumor microenvironment but also shift the phenotype and function of normal immune cells from a possibly anti-tumor state to a pro-tumor state. As a result, tumor cells evade the host's immune system, leading to metastasis and/or recurrent disease.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalMaturitas
Volume105
DOIs
Publication statusPublished - Nov 2017
Externally publishedYes

Keywords

  • Indoleamine-2,3-dioxygenase
  • Major histocompatibility complex
  • Programmed death-ligand 1
  • Siglec-9
  • Tumor escape

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • Obstetrics and Gynaecology

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