The mechanisms tumor cells utilize to evade the host's immune system

Nyanbol Kuol; Lily Stojanovska; Kulmira Nurgali; Vasso Apostolopoulos

doi:10.1016/j.maturitas.2017.04.014

The mechanisms tumor cells utilize to evade the host's immune system

Nyanbol Kuol, Lily Stojanovska, Kulmira Nurgali, Vasso Apostolopoulos

Research output: Contribution to journal › Review article › peer-review

36 Citations (Scopus)

Abstract

The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD-L1, IDO and siglec-9. In addition, tumor cells not only regulate the recruitment and development of immunosuppressive forces to influence the tumor microenvironment but also shift the phenotype and function of normal immune cells from a possibly anti-tumor state to a pro-tumor state. As a result, tumor cells evade the host's immune system, leading to metastasis and/or recurrent disease.

Original language	English
Pages (from-to)	8-15
Number of pages	8
Journal	Maturitas
Volume	105
DOIs	https://doi.org/10.1016/j.maturitas.2017.04.014
Publication status	Published - Nov 2017
Externally published	Yes

Keywords

Indoleamine-2,3-dioxygenase
Major histocompatibility complex
Programmed death-ligand 1
Siglec-9
Tumor escape

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Obstetrics and Gynaecology

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10.1016/j.maturitas.2017.04.014

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title = "The mechanisms tumor cells utilize to evade the host's immune system",

abstract = "The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD-L1, IDO and siglec-9. In addition, tumor cells not only regulate the recruitment and development of immunosuppressive forces to influence the tumor microenvironment but also shift the phenotype and function of normal immune cells from a possibly anti-tumor state to a pro-tumor state. As a result, tumor cells evade the host's immune system, leading to metastasis and/or recurrent disease.",

keywords = "Indoleamine-2,3-dioxygenase, Major histocompatibility complex, Programmed death-ligand 1, Siglec-9, Tumor escape",

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language = "English",

volume = "105",

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T1 - The mechanisms tumor cells utilize to evade the host's immune system

AU - Kuol, Nyanbol

AU - Stojanovska, Lily

AU - Nurgali, Kulmira

AU - Apostolopoulos, Vasso

PY - 2017/11

Y1 - 2017/11

N2 - The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD-L1, IDO and siglec-9. In addition, tumor cells not only regulate the recruitment and development of immunosuppressive forces to influence the tumor microenvironment but also shift the phenotype and function of normal immune cells from a possibly anti-tumor state to a pro-tumor state. As a result, tumor cells evade the host's immune system, leading to metastasis and/or recurrent disease.

AB - The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD-L1, IDO and siglec-9. In addition, tumor cells not only regulate the recruitment and development of immunosuppressive forces to influence the tumor microenvironment but also shift the phenotype and function of normal immune cells from a possibly anti-tumor state to a pro-tumor state. As a result, tumor cells evade the host's immune system, leading to metastasis and/or recurrent disease.

KW - Indoleamine-2,3-dioxygenase

KW - Major histocompatibility complex

KW - Programmed death-ligand 1

KW - Siglec-9

KW - Tumor escape

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DO - 10.1016/j.maturitas.2017.04.014

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JO - Maturitas

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ER -

The mechanisms tumor cells utilize to evade the host's immune system

Abstract

Keywords

ASJC Scopus subject areas

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