The origins of the sciatic nerve and changes in neuropeptides after axotomy: a double labelling study using retrograde transport of Tru blue and vasoactive intestinal polypeptide immunohistochemistry

S. A.S. Shehab, M. E. Atkinson, J. N. Payne

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

One month after sciatic nerve section, only dorsal root ganglion cells which take up True blue applied to the cut end of the nerve show vasoactive intestinal polypeptide immunoreactivity. This indicates that VIP expression is only in cells with damaged axons. Motor axons with True blue-positive perikarya in the ventral horn originate from the fourth to sixth lumbar segments whereas unmyelinated and small myelinated sensory nerves terminate in the third to fifth lumbar segments of the spinal cord.

Original languageEnglish
Pages (from-to)180-185
Number of pages6
JournalBrain Research
Volume376
Issue number1
DOIs
Publication statusPublished - Jun 18 1986
Externally publishedYes

Keywords

  • dorsal root ganglion
  • fluorescence microscopy
  • immunohistochemistry
  • peripheral axotomy
  • retrograde transport
  • sciatic nerve
  • vasoactive intestinal polypeptide (VIP)

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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