TY - JOUR
T1 - The Paradox of quetiapine in obsessive-compulsive disorder
AU - Tranulis, Constantin
AU - Potvin, Stéphane
AU - Gourgue, Martin
AU - Leblanc, Gérard
AU - Mancini-Marïe, Adham
AU - Stip, Emmanuel
PY - 2005/5
Y1 - 2005/5
N2 - Schizophrenia and obsessive-compulsive disorder (OCD) have historical, clinical, and epidemiological links. The clinical use of atypical neuroleptics (ie, dual serotonin-dopamine antagonists) to treat both conditions sheds a new light on them. We report the first two cases of obsessive-compulsive symptoms (OCS) induced by quetiapine in schizophrenia patients. A case of successful augmentation by quetiapine in refractory OCD is also presented. A review of the literature on OCS induced by atypical neuroleptics follows. This paradoxically induced OCD symptomology in schizophrenia patients administered atypical neuroleptics is discussed from new pathophysiological and clinical perspectives. The discussion emphasizes the prognostic implications of OCS in schizophrenia and available therapies for this comorbidity.
AB - Schizophrenia and obsessive-compulsive disorder (OCD) have historical, clinical, and epidemiological links. The clinical use of atypical neuroleptics (ie, dual serotonin-dopamine antagonists) to treat both conditions sheds a new light on them. We report the first two cases of obsessive-compulsive symptoms (OCS) induced by quetiapine in schizophrenia patients. A case of successful augmentation by quetiapine in refractory OCD is also presented. A review of the literature on OCS induced by atypical neuroleptics follows. This paradoxically induced OCD symptomology in schizophrenia patients administered atypical neuroleptics is discussed from new pathophysiological and clinical perspectives. The discussion emphasizes the prognostic implications of OCS in schizophrenia and available therapies for this comorbidity.
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U2 - 10.1017/S1092852900022719
DO - 10.1017/S1092852900022719
M3 - Article
C2 - 15858452
AN - SCOPUS:22344447146
SN - 1092-8529
VL - 10
SP - 356
EP - 361
JO - CNS Spectrums
JF - CNS Spectrums
IS - 5
ER -