The Paradox of quetiapine in obsessive-compulsive disorder

Constantin Tranulis, Stéphane Potvin, Martin Gourgue, Gérard Leblanc, Adham Mancini-Marïe, Emmanuel Stip

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Schizophrenia and obsessive-compulsive disorder (OCD) have historical, clinical, and epidemiological links. The clinical use of atypical neuroleptics (ie, dual serotonin-dopamine antagonists) to treat both conditions sheds a new light on them. We report the first two cases of obsessive-compulsive symptoms (OCS) induced by quetiapine in schizophrenia patients. A case of successful augmentation by quetiapine in refractory OCD is also presented. A review of the literature on OCS induced by atypical neuroleptics follows. This paradoxically induced OCD symptomology in schizophrenia patients administered atypical neuroleptics is discussed from new pathophysiological and clinical perspectives. The discussion emphasizes the prognostic implications of OCS in schizophrenia and available therapies for this comorbidity.

Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalCNS Spectrums
Issue number5
Publication statusPublished - May 2005
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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