The peptidyl-prolyl isomerase pin1 up-regulation and proapoptotic function in dopaminergic neurons: Relevance to the pathogenesis of parkinson disease

Anamitra Ghosh; Hariharan Saminathan; Arthi Kanthasamy; Vellareddy Anantharam; Huajun Jin; Gautam Sondarva; Dilshan S. Harischandra; Ziqing Qian; Ajay Rana; Anumantha G. Kanthasamy

doi:10.1074/jbc.M112.444224

The peptidyl-prolyl isomerase pin1 up-regulation and proapoptotic function in dopaminergic neurons: Relevance to the pathogenesis of parkinson disease

Anamitra Ghosh
, Hariharan Saminathan
, Arthi Kanthasamy
, Vellareddy Anantharam
, Huajun Jin
, Gautam Sondarva
, Dilshan S. Harischandra
, Ziqing Qian
, Ajay Rana
, Anumantha G. Kanthasamy

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Background: Pin1 regulates several signaling proteins by isomerizing the cis/trans conformation of the Ser(P)-Pro peptide bond. Results: Pin1 is up-regulated in dopaminergic neurons in cell culture, animal models, and human PD brains. Pin1 inhibition protects dopaminergic neurons in PD models. Conclusion: Pin1 up-regulation plays a proapoptotic function in PD. Significance: Pin1 inhibition may be a viable translational strategy in PD.

Original language	English
Pages (from-to)	21955-21971
Number of pages	17
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M112.444224
Publication status	Published - Jul 26 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Ghosh, A., Saminathan, H., Kanthasamy, A., Anantharam, V., Jin, H., Sondarva, G., Harischandra, D. S., Qian, Z., Rana, A., & Kanthasamy, A. G. (2013). The peptidyl-prolyl isomerase pin1 up-regulation and proapoptotic function in dopaminergic neurons: Relevance to the pathogenesis of parkinson disease. Journal of Biological Chemistry, 288(30), 21955-21971. https://doi.org/10.1074/jbc.M112.444224

Ghosh, A, Saminathan, H, Kanthasamy, A, Anantharam, V, Jin, H, Sondarva, G, Harischandra, DS, Qian, Z, Rana, A & Kanthasamy, AG 2013, 'The peptidyl-prolyl isomerase pin1 up-regulation and proapoptotic function in dopaminergic neurons: Relevance to the pathogenesis of parkinson disease', Journal of Biological Chemistry, vol. 288, no. 30, pp. 21955-21971. https://doi.org/10.1074/jbc.M112.444224

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abstract = "Background: Pin1 regulates several signaling proteins by isomerizing the cis/trans conformation of the Ser(P)-Pro peptide bond. Results: Pin1 is up-regulated in dopaminergic neurons in cell culture, animal models, and human PD brains. Pin1 inhibition protects dopaminergic neurons in PD models. Conclusion: Pin1 up-regulation plays a proapoptotic function in PD. Significance: Pin1 inhibition may be a viable translational strategy in PD.",

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AU - Kanthasamy, Arthi

AU - Anantharam, Vellareddy

AU - Jin, Huajun

AU - Sondarva, Gautam

AU - Harischandra, Dilshan S.

AU - Qian, Ziqing

AU - Rana, Ajay

AU - Kanthasamy, Anumantha G.

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AB - Background: Pin1 regulates several signaling proteins by isomerizing the cis/trans conformation of the Ser(P)-Pro peptide bond. Results: Pin1 is up-regulated in dopaminergic neurons in cell culture, animal models, and human PD brains. Pin1 inhibition protects dopaminergic neurons in PD models. Conclusion: Pin1 up-regulation plays a proapoptotic function in PD. Significance: Pin1 inhibition may be a viable translational strategy in PD.

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The peptidyl-prolyl isomerase pin1 up-regulation and proapoptotic function in dopaminergic neurons: Relevance to the pathogenesis of parkinson disease

Abstract

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