The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan

Thoraya M.E. A-Elgadir; Mustafa I. Elbashir; Klavs Berzins; Emad M. Masuadi; Ishraga E. A-Elbasit; Gehad ElGhazali; Hayder A. Giha

doi:10.1007/s00436-007-0777-3

The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan

Thoraya M.E. A-Elgadir, Mustafa I. Elbashir, Klavs Berzins, Emad M. Masuadi, Ishraga E. A-Elbasit, Gehad ElGhazali, Hayder A. Giha

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this study, antibodies (Ab) directed against three MSP antigens; MSP1₁₉, MSP2_A, and MSP2_B were analyzed in blood samples obtained from 223 Sudanese patients who presented with either severe malaria (SM) or uncomplicated malaria (UM) and from 117 malaria-free donors (MF). The results showed that the prevalence of MSP Abs was associated with the clinical outcome of malaria infection, and the Ab prevalence was age-dependent (P < 0.0005). More importantly, the prevalence of MSP Abs against the test antigens was lower in SM compared to UM (P = 0.001 to 0.020), suggesting a protective role for these Abs against SM. Furthermore, the Ab responses between individual complications of SM were significantly different.

Original language	English
Pages (from-to)	401-409
Number of pages	9
Journal	Parasitology Research
Volume	102
Issue number	3
DOIs	https://doi.org/10.1007/s00436-007-0777-3
Publication status	Published - Feb 2008
Externally published	Yes

ASJC Scopus subject areas

Parasitology
General Veterinary
Insect Science
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00436-007-0777-3

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title = "The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan",

abstract = "In this study, antibodies (Ab) directed against three MSP antigens; MSP119, MSP2A, and MSP2B were analyzed in blood samples obtained from 223 Sudanese patients who presented with either severe malaria (SM) or uncomplicated malaria (UM) and from 117 malaria-free donors (MF). The results showed that the prevalence of MSP Abs was associated with the clinical outcome of malaria infection, and the Ab prevalence was age-dependent (P < 0.0005). More importantly, the prevalence of MSP Abs against the test antigens was lower in SM compared to UM (P = 0.001 to 0.020), suggesting a protective role for these Abs against SM. Furthermore, the Ab responses between individual complications of SM were significantly different.",

author = "A-Elgadir, {Thoraya M.E.} and Elbashir, {Mustafa I.} and Klavs Berzins and Masuadi, {Emad M.} and A-Elbasit, {Ishraga E.} and Gehad ElGhazali and Giha, {Hayder A.}",

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doi = "10.1007/s00436-007-0777-3",

language = "English",

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journal = "Parasitology Research",

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T1 - The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan

AU - A-Elgadir, Thoraya M.E.

AU - Elbashir, Mustafa I.

AU - Berzins, Klavs

AU - Masuadi, Emad M.

AU - A-Elbasit, Ishraga E.

AU - ElGhazali, Gehad

AU - Giha, Hayder A.

PY - 2008/2

Y1 - 2008/2

N2 - In this study, antibodies (Ab) directed against three MSP antigens; MSP119, MSP2A, and MSP2B were analyzed in blood samples obtained from 223 Sudanese patients who presented with either severe malaria (SM) or uncomplicated malaria (UM) and from 117 malaria-free donors (MF). The results showed that the prevalence of MSP Abs was associated with the clinical outcome of malaria infection, and the Ab prevalence was age-dependent (P < 0.0005). More importantly, the prevalence of MSP Abs against the test antigens was lower in SM compared to UM (P = 0.001 to 0.020), suggesting a protective role for these Abs against SM. Furthermore, the Ab responses between individual complications of SM were significantly different.

AB - In this study, antibodies (Ab) directed against three MSP antigens; MSP119, MSP2A, and MSP2B were analyzed in blood samples obtained from 223 Sudanese patients who presented with either severe malaria (SM) or uncomplicated malaria (UM) and from 117 malaria-free donors (MF). The results showed that the prevalence of MSP Abs was associated with the clinical outcome of malaria infection, and the Ab prevalence was age-dependent (P < 0.0005). More importantly, the prevalence of MSP Abs against the test antigens was lower in SM compared to UM (P = 0.001 to 0.020), suggesting a protective role for these Abs against SM. Furthermore, the Ab responses between individual complications of SM were significantly different.

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The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan

Abstract

ASJC Scopus subject areas

UN SDGs

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