TY - JOUR
T1 - The protective effects of Cyperus rotundus on behavior and cognitive function in a rat model of hypoxia injury
AU - Jebasingh, Dhas
AU - Devavaram Jackson, Dhas
AU - Venkataraman, S.
AU - Adeghate, Ernest
AU - Starling Emerald, Bright
N1 - Publisher Copyright:
© 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Context: Hypoxia injury (HI) with its long-term neurological complications is one of the leading causes of morbidity and mortality in the world. Currently, the treatment regimens for hypoxia are aimed only at ameliorating the damage without complete cure. The need, therefore, for novel therapeutic drugs to treat HI continues. Objective: This study investigates the protective effects of the ethanol extract of Cyperus rotundus L. (Cyperaceae) (EECR), a medicinal plant used in Ayurvedic traditional medicine against sodium nitrite-induced hypoxia in rats. Materials and methods: We have evaluated the protective effect of 200 and 400mg/kg of EECR against sodium nitrite-induced hypoxia injury in rats by assessing the cognitive functions, motor, and behavioral effects of EECR treatment along with the histological changes in the brain. By comparing the protective effects of standard drugs galantamine, a reversible cholinesterase inhibitor and pyritinol, an antioxidant nootropic drug against sodium nitrite-induced hypoxia in rats, we have tested the protective ability of EECR. Results: EECR at doses of 200 and 400mg/kg was able to protect against the cognitive impairments, and the locomotor activity and muscular coordination defects, which are affected by sodium nitrite-induced hypoxia injury in rats. Conclusion: Based on our results, we suggest that the medicinal herb C. rotundus possesses a protective effect against sodium nitrite-induced hypoxia in rats. Further studies on these protective effects of EECR may help in designing better therapeutic regimes for hypoxia injury.
AB - Context: Hypoxia injury (HI) with its long-term neurological complications is one of the leading causes of morbidity and mortality in the world. Currently, the treatment regimens for hypoxia are aimed only at ameliorating the damage without complete cure. The need, therefore, for novel therapeutic drugs to treat HI continues. Objective: This study investigates the protective effects of the ethanol extract of Cyperus rotundus L. (Cyperaceae) (EECR), a medicinal plant used in Ayurvedic traditional medicine against sodium nitrite-induced hypoxia in rats. Materials and methods: We have evaluated the protective effect of 200 and 400mg/kg of EECR against sodium nitrite-induced hypoxia injury in rats by assessing the cognitive functions, motor, and behavioral effects of EECR treatment along with the histological changes in the brain. By comparing the protective effects of standard drugs galantamine, a reversible cholinesterase inhibitor and pyritinol, an antioxidant nootropic drug against sodium nitrite-induced hypoxia in rats, we have tested the protective ability of EECR. Results: EECR at doses of 200 and 400mg/kg was able to protect against the cognitive impairments, and the locomotor activity and muscular coordination defects, which are affected by sodium nitrite-induced hypoxia injury in rats. Conclusion: Based on our results, we suggest that the medicinal herb C. rotundus possesses a protective effect against sodium nitrite-induced hypoxia in rats. Further studies on these protective effects of EECR may help in designing better therapeutic regimes for hypoxia injury.
KW - EECR
KW - Galantamine
KW - Neuroprotection
KW - Pyritinol
KW - Sodium nitrite
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U2 - 10.3109/13880209.2014.908395
DO - 10.3109/13880209.2014.908395
M3 - Article
C2 - 25026346
AN - SCOPUS:84907976762
SN - 1388-0209
VL - 52
SP - 1558
EP - 1569
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 12
ER -