The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus

Sanabil Ali Hassan Ahmed, Suraiya Anjum Ansari, Eric P.K. Mensah-Brown, Bright Starling Emerald

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Diabetes mellitus (DM) is a chronic condition characterised by β cell dysfunction and persistent hyperglycaemia. The disorder can be due to the absence of adequate pancreatic insulin production or a weak cellular response to insulin signalling. Among the three types of DM, namely, type 1 DM (T1DM), type 2 DM (T2DM), and gestational DM (GDM); T2DM accounts for almost 90% of diabetes cases worldwide. Epigenetic traits are stably heritable phenotypes that result from certain changes that affect gene function without altering the gene sequence. While epigenetic traits are considered reversible modifications, they can be inherited mitotically and meiotically. In addition, epigenetic traits can randomly arise in response to environmental factors or certain genetic mutations or lesions, such as those affecting the enzymes that catalyse the epigenetic modification. In this review, we focus on the role of DNA methylation, a type of epigenetic modification, in the pathogenesis of T2DM.

Original languageEnglish
Article number104
JournalClinical Epigenetics
Volume12
Issue number1
DOIs
Publication statusPublished - Jul 11 2020

Keywords

  • DNA methylation
  • Diabetes mellitus
  • Hypermethylation
  • Hypomethylation
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology
  • Genetics(clinical)

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