The role of endothelin in early renal cortical reperfusion in renal transplantation

F. T. Hammad, G. Davis, X. Zhang, A. M. Wheatley

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The role of specific endothelin receptors in the early renal reperfusion and long-term survival in renal transplantation was investigated in Lewis rats. Left renal transplantation was performed following 2 h cold ischaemia without and with ETA receptor antagonism and following 16 h cold ischaemia with no treatment, with ETA receptor antagonism and with ETB receptor antagonism. The ETA and ETB receptor antagonists, BQ-610 and A-192621 respectively, were added to the preservation solution. Renal cortical perfusion (RCP) was measured postoperatively using laser Doppler flowmetry. All rats in the 2-hour groups survived for 15 days. Animals in the untreated 16-hour group or in the A-192621-treated group died between days 3 and 6 after surgery. Fifty percent of the rats in the 16-hour and BQ-610-treated group died between days 4 and 7 after surgery while the other 50% survived for 15 days. Survival rates correlated well with both the postoperative serum creatinine and the recovery of RCP. We conclude that addition of an ETA receptor antagonist to the preservation solution improves renal reperfusion and long-term survival following prolonged ischaemia, whereas ETB receptor antagonism does neither.

Original languageEnglish
Pages (from-to)380-388
Number of pages9
JournalEuropean Surgical Research
Issue number6
Publication statusPublished - 2000
Externally publishedYes


  • Cold ischaemia-reperfusion injury
  • Endothelin antagonism
  • Renal cortical perfusion

ASJC Scopus subject areas

  • Surgery


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