The role of the vascular endothelium in the contractile responses of human chorionic plate artery in pre-eclampsia to prostaglandin F2alpha, 5-hydroxytryptamine, and potassium chloride

M. Ezimokhai, C. P. Aloamaka, N. A. Osman, E. P.K. Mensah-Brown, J. Morrison

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

This study characterises the reactivity of chorionic plate artery in preeclampsia to prostaglandin F2alpha (PGF2alpha), 5-hydroxytryptamine (5-HT), and potassium chloride (KCl) and examines the role of the vascular endothelium in these responses. Ring segments of the chorionic plate arteries of women after normal and pre-eclamptic pregnancies were contracted by PGF2alpha, 5-HT, and KCl. The experiments were carried out in the presence and absence of endothelium, and on intact rings treated with 10-6M indomethacin. The maximal contractile responses of rings from pre-eclamptic women to 5-HT, PGF2alpha, or KCl were significantly greater than those of rings from normotensive pregnant women. The EC50 values of responses were significantly lower in rings from pre-eclamptic subjects. Endothelium removal and treatment of the rings with indomethacin had no effect on the contractile responses of rings from normotensive pregnant women to all the agents, but significantly increased the EC50 value and decreased the maximal contractile responses of rings from pre-eclamptic women to 5-HT and PGF2alpha. While de-endothelialisation increased the EC50 value for responses of the rings from pre-eclamptic women to KCl, pretreatment with indomethacin did not significantly affect the KCl-induced responses. The results of the study suggest that pre-eclampsia enhanced the reactivity of human chorionic plate artery to 5-HT, PGF2alpha, and KCl through the involvement of endothelial derived contracting factors. The increased responses to 5-HT and PGF2alpha were inhibited by indomethacin, but those to KCl were not.

Original languageEnglish
Pages (from-to)171-182
Number of pages12
JournalResearch in Experimental Medicine
Volume195
Issue number1
DOIs
Publication statusPublished - Dec 1995

Keywords

  • Chorionic plate artery
  • Contractile responses
  • Pre-eclampsia

ASJC Scopus subject areas

  • General Medicine

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