The screen for cognitive impairment in psychiatry (SCIP) is associated with disease severity and cognitive complaints in major depression

Objective: To assess the relationship between the Screen for Cognitive Impairment in Psychiatry (SCIP) score and illness severity, subjective cognition and functioning in a cohort of major depressive disorder (MDD) patients. Methods: Patients (n = 40) diagnosed with MDD (DSM-IV-TR) completed the SCIP, a brief neuropsychological test, and a battery of self-administered questionnaires evaluating functioning (GAF, SDS, WHODAS 2.0, EDEC, PDQ-D5). Disease severity was evaluated with the Hamilton Depression Rating Scale (HDRS) and the Clinical Global Impression (CGI). Results: Age and sex were associated with performance in the SCIP. The SCIP-Global index score was associated with disease severity (r = −0.316, p <.05), the SDS, a patient self-assessment of daily functioning (r = −0.368, p <.05), and the EDEC subscales of patient-reported cognitive deficits (r = −0.388, p <.05) and their functional impacts (r = −0.335, p <.05). Multivariate analysis adjusted for age and sex confirmed these tests are independent predictors of performance in the SCIP (CGI-S, F _[3,34] = 4.478, p =.009; SDS, F _[3,34] = 3.365, p =.030; EDEC-perceived cognitive deficits, F _[3,34] = 5.216, p =.005; EDEC-perceived impacts of functional impairment, F _[3,34] = 5.154, p =.005). Conclusions: This study confirms that the SCIP can be used during routine clinical evaluation of MDD, and that cognitive deficits objectively assessed in the SCIP are associated with disease severity and self-reported cognitive dysfunction and impairment in daily life.