The search for a tuberculosis vaccine: An elusive quest?

Nico J.D. Nagelkerke; Sake J. De Vlas; Yodi Mahendradhata; Tom H.M. Ottenhoff; Martien Borgdorff

doi:10.1016/j.tube.2005.06.001

The search for a tuberculosis vaccine: An elusive quest?

Nico J.D. Nagelkerke, Sake J. De Vlas, Yodi Mahendradhata, Tom H.M. Ottenhoff, Martien Borgdorff

Department of Public Health Institute

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The precise mechanisms of protective immunity and pathogenesis of tuberculosis (TB) are poorly understood. Yet, many efforts are underway to develop new, more effective vaccines against Mycobacterium tuberculosis. This development appears to be predicated upon the assumption that natural acquired immunity to TB exists. In this paper we review the evidence for such immunity, explore the hypothesis that disease progression is due to some, often transient, immunological dysfunction, and discuss its relevance for vaccine development. Several mechanisms for such an immune dysfunction are proposed, including the recently suggested involvement of viral co-infections. Developing vaccines for such co-infections may be a new challenge for TB control.

Original language	English
Pages (from-to)	41-46
Number of pages	6
Journal	Tuberculosis
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/j.tube.2005.06.001
Publication status	Published - Jan 2006

Keywords

Coinfections
Immunity
Tuberculosis
Vaccines

ASJC Scopus subject areas

Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tube.2005.06.001

Cite this

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title = "The search for a tuberculosis vaccine: An elusive quest?",

abstract = "The precise mechanisms of protective immunity and pathogenesis of tuberculosis (TB) are poorly understood. Yet, many efforts are underway to develop new, more effective vaccines against Mycobacterium tuberculosis. This development appears to be predicated upon the assumption that natural acquired immunity to TB exists. In this paper we review the evidence for such immunity, explore the hypothesis that disease progression is due to some, often transient, immunological dysfunction, and discuss its relevance for vaccine development. Several mechanisms for such an immune dysfunction are proposed, including the recently suggested involvement of viral co-infections. Developing vaccines for such co-infections may be a new challenge for TB control.",

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AU - Nagelkerke, Nico J.D.

AU - De Vlas, Sake J.

AU - Mahendradhata, Yodi

AU - Ottenhoff, Tom H.M.

AU - Borgdorff, Martien

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AB - The precise mechanisms of protective immunity and pathogenesis of tuberculosis (TB) are poorly understood. Yet, many efforts are underway to develop new, more effective vaccines against Mycobacterium tuberculosis. This development appears to be predicated upon the assumption that natural acquired immunity to TB exists. In this paper we review the evidence for such immunity, explore the hypothesis that disease progression is due to some, often transient, immunological dysfunction, and discuss its relevance for vaccine development. Several mechanisms for such an immune dysfunction are proposed, including the recently suggested involvement of viral co-infections. Developing vaccines for such co-infections may be a new challenge for TB control.

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KW - Vaccines

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The search for a tuberculosis vaccine: An elusive quest?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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