TY - JOUR
T1 - The synthesis of novel hybrid compounds containing 5-nitrothiazole moiety as potential antiparasitic agents
AU - Saleh, Yasmin R.H.
AU - Saadeh, Haythem A.
AU - Kaur, Hargobinder
AU - Goyal, Kapil
AU - Sehgal, Rakesh
AU - Mubarak, Mohammad S.
N1 - Publisher Copyright:
© 2015 Springer-Verlag Wien.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - A number of novel compounds containing 5-nitrothiazole moiety as potential antiparasitic agents have been synthesized through known chemical routes. The structures of the new compounds were confirmed by spectroscopic techniques, 1H NMR, 13C NMR, and mass spectrometry, and by elemental analyses. The prepared compounds were evaluated in vitro for their antigiardial and antitrichomonal activities. All tested compounds exhibited remarkable antigiardial activity with IC50 values ranging from 2.2 to 6.9 μg/cm3 as compared to the reference drug metronidazole (IC50 = 7.3 μg/cm3). In addition, three of the prepared compounds exhibited significant antitrichomonal activity with IC50 values of 4.3, 5.0, and 7.9 μg/cm3, respectively, as compared to the reference drug metronidazole (8.5 μg/cm3). Graphical abstract: [Figure not available: see fulltext.]
AB - A number of novel compounds containing 5-nitrothiazole moiety as potential antiparasitic agents have been synthesized through known chemical routes. The structures of the new compounds were confirmed by spectroscopic techniques, 1H NMR, 13C NMR, and mass spectrometry, and by elemental analyses. The prepared compounds were evaluated in vitro for their antigiardial and antitrichomonal activities. All tested compounds exhibited remarkable antigiardial activity with IC50 values ranging from 2.2 to 6.9 μg/cm3 as compared to the reference drug metronidazole (IC50 = 7.3 μg/cm3). In addition, three of the prepared compounds exhibited significant antitrichomonal activity with IC50 values of 4.3, 5.0, and 7.9 μg/cm3, respectively, as compared to the reference drug metronidazole (8.5 μg/cm3). Graphical abstract: [Figure not available: see fulltext.]
KW - 5-Nitrothiazole
KW - Antigiardial activity
KW - Antitrichomonal activity
KW - Chloroquine
KW - Hybrid molecules
KW - Metronidazole
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U2 - 10.1007/s00706-015-1511-y
DO - 10.1007/s00706-015-1511-y
M3 - Article
AN - SCOPUS:84947494394
SN - 0026-9247
VL - 146
SP - 2087
EP - 2095
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
IS - 12
ER -