The Two Period Binary Response Cross‐Over Trial

N. J.D. Nagelkerke, A. A.M. Hart, J. Oosting

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The cross‐over design for clinical trials when responses are binary is discussed. Three tests which have been proposed for the analysis of this problem are compared by an assessment of their assumptions. A simple test to establish whether it is appropriate to include observations from the second period is presented.

Original languageEnglish
Pages (from-to)863-869
Number of pages7
JournalBiometrical Journal
Issue number7
Publication statusPublished - 1986
Externally publishedYes


  • Carry‐over effects
  • Clinical trials
  • Cross‐over design
  • Hypothesis testing

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty


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