The Two Period Binary Response Cross‐Over Trial

N. J.D. Nagelkerke; A. A.M. Hart; J. Oosting

doi:10.1002/bimj.4710280715

The Two Period Binary Response Cross‐Over Trial

N. J.D. Nagelkerke, A. A.M. Hart, J. Oosting

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The cross‐over design for clinical trials when responses are binary is discussed. Three tests which have been proposed for the analysis of this problem are compared by an assessment of their assumptions. A simple test to establish whether it is appropriate to include observations from the second period is presented.

Original language	English
Pages (from-to)	863-869
Number of pages	7
Journal	Biometrical Journal
Volume	28
Issue number	7
DOIs	https://doi.org/10.1002/bimj.4710280715
Publication status	Published - 1986
Externally published	Yes

Keywords

Carry‐over effects
Clinical trials
Cross‐over design
Hypothesis testing

ASJC Scopus subject areas

Statistics and Probability
Statistics, Probability and Uncertainty

Access to Document

10.1002/bimj.4710280715

Cite this

@article{205079122d114f5eba4c92452301ae30,

title = "The Two Period Binary Response Cross‐Over Trial",

abstract = "The cross‐over design for clinical trials when responses are binary is discussed. Three tests which have been proposed for the analysis of this problem are compared by an assessment of their assumptions. A simple test to establish whether it is appropriate to include observations from the second period is presented.",

keywords = "Carry‐over effects, Clinical trials, Cross‐over design, Hypothesis testing",

author = "Nagelkerke, {N. J.D.} and Hart, {A. A.M.} and J. Oosting",

year = "1986",

doi = "10.1002/bimj.4710280715",

language = "English",

volume = "28",

pages = "863--869",

journal = "Biometrical Journal",

issn = "0323-3847",

publisher = "Wiley-VCH Verlag",

number = "7",

}

TY - JOUR

T1 - The Two Period Binary Response Cross‐Over Trial

AU - Nagelkerke, N. J.D.

AU - Hart, A. A.M.

AU - Oosting, J.

PY - 1986

Y1 - 1986

N2 - The cross‐over design for clinical trials when responses are binary is discussed. Three tests which have been proposed for the analysis of this problem are compared by an assessment of their assumptions. A simple test to establish whether it is appropriate to include observations from the second period is presented.

AB - The cross‐over design for clinical trials when responses are binary is discussed. Three tests which have been proposed for the analysis of this problem are compared by an assessment of their assumptions. A simple test to establish whether it is appropriate to include observations from the second period is presented.

KW - Carry‐over effects

KW - Clinical trials

KW - Cross‐over design

KW - Hypothesis testing

UR - http://www.scopus.com/inward/record.url?scp=84982021431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982021431&partnerID=8YFLogxK

U2 - 10.1002/bimj.4710280715

DO - 10.1002/bimj.4710280715

M3 - Article

AN - SCOPUS:84982021431

SN - 0323-3847

VL - 28

SP - 863

EP - 869

JO - Biometrical Journal

JF - Biometrical Journal

IS - 7

ER -

The Two Period Binary Response Cross‐Over Trial

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this