The type B leukemogenic virus truncated superantigen is dispensable for T-cell lymphomagenesis

Farah Mustafa, Sanchita Bhadra, Dennis Johnston, Mary Lozano, Jaquelin P. Dudley

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Type B leukemogenic virus (TBLV) is a variant of mouse mammary tumor virus (MMTV) that causes T-cell lymphomas in mice. We have constructed a TBLV-MMTV hybrid, pHYB-TBLV, in which 756 bp of the C3H MMTV long terminal repeat (LTR) was replaced with 438 bp of the TBLV LTR. Intraperitoneal injection of pHYB-TBLV transfectants consistently resulted in T-cell lymphomas in 50% of injected weanling BALB/c mice with an average latency period of 5.7 (± 1.5) months. Transfectants of pHYB-TBLV containing a double-frameshift mutation in the truncated superantigen gene (sag) induced T-cell lymphomas with similar incidences, latency periods, and phenotypes, suggesting that cis-acting elements in the TBLV LTR determine disease specificity.

Original languageEnglish
Pages (from-to)3866-3870
Number of pages5
JournalJournal of Virology
Volume77
Issue number6
DOIs
Publication statusPublished - Mar 2003

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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