Three-Year Naturalistic Study On Early Use Of Long-Acting Injectable Antipsychotics In First Episode Psychosis

Sofia Medrano, Amal Abdel-Baki, Emmanuel Stip, Stéphane Potvin

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Abstract: Poor adherence to antipsychotics, which affects outcome, is frequent in first episode psychosis (FEP). Most randomized studies demonstrate no superiority of long-acting injectable antipsychotics (LAI-AP) over oral antipsychotics (OAP). However, participants in these studies represent a minority of patients who may benefit from LAI-AP. Mirror and naturalistic studies generally demonstrate efficacy of LAI-AP on more representative samples, but studies on FEP are scarce. Aim: To describe LAI-AP's utilization and impact on FEP outcome in a naturalistic setting. Methods: A 3-year longitudinal prospective and retrospective descriptive study of all consecutive admissions from two Early Intervention Services for psychosis (EIS) in Montréal, Canada, compared the characteristics and evolution of patients who received LAI-AP for at least 12 months to those who received OAP only. Results: From 375 FEP patients included, 26,7% received LAI-AP during their follow-up. They were more likely to have poor prognostic factors (male gender, lower premorbid functioning, homelessness, substance use disorder and schizophrenia spectrum diagnoses). Despite a more severe illness and lower functioning in the LAI-AP group, at admission and study endpoint, clinical and functional improvements were observed. Conclusion: Early prescription of LAI-AP seems beneficial in FEP with poor prognostic factors.

Original languageEnglish
Pages (from-to)25-61
Number of pages37
JournalPsychopharmacology Bulletin
Issue number4
Publication statusPublished - Jun 20 2018
Externally publishedYes


  • clinical outcomes
  • first-episode psychosis
  • long-acting injectable antipsychotics
  • observational study
  • psychotic disorders
  • schizophrenia spectrum

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


Dive into the research topics of 'Three-Year Naturalistic Study On Early Use Of Long-Acting Injectable Antipsychotics In First Episode Psychosis'. Together they form a unique fingerprint.

Cite this