Abstract
The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10-3 (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.
Original language | English |
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Pages (from-to) | 29-35 |
Number of pages | 7 |
Journal | Cancer Letters |
Volume | 118 |
Issue number | 1 |
DOIs | |
Publication status | Published - Sept 16 1997 |
Externally published | Yes |
Keywords
- Chemosensitivity
- Chemotherapy
- Colorectal cancer
- Hepatic artery infusion
- Predictive parameter
- Thymidylate synthase
ASJC Scopus subject areas
- Oncology
- Cancer Research