Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

Marko Kornmann, Karl H. Link, Heinz Josef Lenz, Jürgen Pillasch, Ralf Metzger, Urwe Butzer, Gerhard H. Leder, Marlen Weindel, Farouk Safi, Kathleen D. Danenberg, Hans G. Beger, Peter V. Danenberg

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10-3 (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalCancer Letters
Volume118
Issue number1
DOIs
Publication statusPublished - Sep 16 1997

Keywords

  • Chemosensitivity
  • Chemotherapy
  • Colorectal cancer
  • Hepatic artery infusion
  • Predictive parameter
  • Thymidylate synthase

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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