Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

Marko Kornmann; Karl H. Link; Heinz Josef Lenz; Jürgen Pillasch; Ralf Metzger; Urwe Butzer; Gerhard H. Leder; Marlen Weindel; Farouk Safi; Kathleen D. Danenberg; Hans G. Beger; Peter V. Danenberg

doi:10.1016/S0304-3835(97)00220-6

Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

Marko Kornmann
, Karl H. Link
, Heinz Josef Lenz
, Jürgen Pillasch
, Ralf Metzger
, Urwe Butzer
, Gerhard H. Leder
, Marlen Weindel
, Farouk Safi
, Kathleen D. Danenberg
, Hans G. Beger
, Peter V. Danenberg

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10^-3 (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.

Original language	English
Pages (from-to)	29-35
Number of pages	7
Journal	Cancer Letters
Volume	118
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(97)00220-6
Publication status	Published - Sept 16 1997
Externally published	Yes

Keywords

Chemosensitivity
Chemotherapy
Colorectal cancer
Hepatic artery infusion
Predictive parameter
Thymidylate synthase

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(97)00220-6

Cite this

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title = "Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy",

abstract = "The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10-3 (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.",

keywords = "Chemosensitivity, Chemotherapy, Colorectal cancer, Hepatic artery infusion, Predictive parameter, Thymidylate synthase",

author = "Marko Kornmann and Link, \{Karl H.\} and Lenz, \{Heinz Josef\} and J{\"u}rgen Pillasch and Ralf Metzger and Urwe Butzer and Leder, \{Gerhard H.\} and Marlen Weindel and Farouk Safi and Danenberg, \{Kathleen D.\} and Beger, \{Hans G.\} and Danenberg, \{Peter V.\}",

year = "1997",

month = sep,

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doi = "10.1016/S0304-3835(97)00220-6",

language = "English",

volume = "118",

pages = "29--35",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

AU - Kornmann, Marko

AU - Link, Karl H.

AU - Lenz, Heinz Josef

AU - Pillasch, Jürgen

AU - Metzger, Ralf

AU - Butzer, Urwe

AU - Leder, Gerhard H.

AU - Weindel, Marlen

AU - Safi, Farouk

AU - Danenberg, Kathleen D.

AU - Beger, Hans G.

AU - Danenberg, Peter V.

PY - 1997/9/16

Y1 - 1997/9/16

N2 - The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10-3 (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.

AB - The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10-3 (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.

KW - Chemosensitivity

KW - Chemotherapy

KW - Colorectal cancer

KW - Hepatic artery infusion

KW - Predictive parameter

KW - Thymidylate synthase

UR - https://www.scopus.com/pages/publications/0345973521

UR - https://www.scopus.com/pages/publications/0345973521#tab=citedBy

U2 - 10.1016/S0304-3835(97)00220-6

DO - 10.1016/S0304-3835(97)00220-6

M3 - Article

C2 - 9310257

AN - SCOPUS:0345973521

SN - 0304-3835

VL - 118

SP - 29

EP - 35

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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