Thymoquinone Produces Cardioprotective Effect in β-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation

Sumit Rathod, Yogeeta Agrawal, Abdulla Sherikar, Kartik T. Nakhate, Chandragouda R. Patil, M. F. Nagoor Meeran, Shreesh Ojha, Sameer N. Goyal

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Earlier studies reported that long-term treatment with thymoquinone (TQ) at a high dose (20 mg/kg) exerts a cardioprotective effect against isoproterenol (ISO)-triggered myocardial infarction (MI) in rats. In the present study, we tested the hypothesis that TQ, as a potent molecule, can exhibit cardioprotective effects at the lower dose for a short-term regimen. The rats were administered with TQ (5 mg/kg, intraperitoneal) at the 4 h interval for 2 days. ISO (100 mg/kg/day, subcutaneous) was given for 2 days to produce MI. ISO challenge results in deformation in ECG wave front, elevated left ventricular (LV) end-diastolic pressure, and reduced LVdP/dtmax and LVdP/dtmin. The levels of the cardiac biomarker in serum, such as creatine kinase MB, alanine aminotransferase, and aspartate aminotransferase, were increased. In the myocardium, a rise in malonaldehyde and decreased superoxide dismutase, glutathione, and catalase contents were observed. Furthermore, increased levels of tumor necrotic factor-α, interleukin-6, and interleukin-1β were observed in the myocardium. TQ pretreatment significantly normalized alterations in hemodynamic parameters, strengthened the antioxidant defense system, and decreased the contents of pro-inflammatory cytokines and hepatic enzymes as compared to the ISO group. Based on the results, TQ appears to be cardioprotective at low doses, and effective even administered for a shorter duration.

Original languageEnglish
Article number2742
JournalNutrients
Volume14
Issue number13
DOIs
Publication statusPublished - Jul 1 2022

Keywords

  • antioxidant
  • glutathione
  • hemodynamic
  • myocardium
  • pro-inflammatory mediators

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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