Total Stromal Fraction (TSF)-Fortified Adipose Tissue-Derived Stem Cells Source: An Emerging Regenerative Realm Against COVID-19 In-duced Pulmonary Compromise

Madhan Jeyaraman, Sathish Muthu, Rashmi Jain, Ajay Shringeri Satish, Neha Garg, Prabhu Chandra Mishra, Kumari Swati, Anand Parkash, Niraj Kumar Jha, Shreesh Ojha, Shubhadeep Roychoudhury, Dhruv Kumar, Janne Ruokolainen, Mohammad Amjad Kamal, Kavindra Kumar Kesari, Saurabh Kumar Jha

Research output: Contribution to journalReview articlepeer-review

Abstract

The inception of the COVID-19 pandemic has jeopardized humanity with markedly dam-pening of worldwide resources. The viral infection may present with varying signs and symptoms, imitating pneumonia and seasonal flu. With a gradual course, this may progress and result in the deadliest state of acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). More-over, following recovery from the severe brunt of COVID-19 infection, interstitial portions of alve-oli have been found to undergo residual scarring and further to have compromised air exchange. Such alterations in the lung microenvironment and associated systemic manifestations have been recognized to occur due to the extensive release of cytokines. The mortality rate increases with advancing age and in individuals with underlying co-morbidity. Presently, there is no availability of specific antiviral therapy or any other definitive modality to counter this progressive worsening. However, we believe principles and advancing cell-based therapy may prove fruitful in subjugating such reported worsening in these patients. This article reviews eminent knowledge and relevant ad-vancements about the amelioration of lung damage due to COVID-19 infection using adipose tis-sue-derived-total stromal fraction (TSF).

Original languageEnglish
Article numbere221221196287
Pages (from-to)56-64
Number of pages9
JournalCoronaviruses
Volume3
Issue number1
DOIs
Publication statusPublished - 2022

Keywords

  • COVID-19
  • Cytokines
  • TSF
  • adipose tissue-derived MSCs
  • corona related pulmonary compromise
  • total stromal fraction

ASJC Scopus subject areas

  • Immunology and Microbiology (miscellaneous)
  • Pulmonary and Respiratory Medicine
  • Virology
  • Infectious Diseases

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