TY - JOUR
T1 - Total Stromal Fraction (TSF)-Fortified Adipose Tissue-Derived Stem Cells Source
T2 - An Emerging Regenerative Realm Against COVID-19 In-duced Pulmonary Compromise
AU - Jeyaraman, Madhan
AU - Muthu, Sathish
AU - Jain, Rashmi
AU - Satish, Ajay Shringeri
AU - Garg, Neha
AU - Mishra, Prabhu Chandra
AU - Swati, Kumari
AU - Parkash, Anand
AU - Jha, Niraj Kumar
AU - Ojha, Shreesh
AU - Roychoudhury, Shubhadeep
AU - Kumar, Dhruv
AU - Ruokolainen, Janne
AU - Kamal, Mohammad Amjad
AU - Kesari, Kavindra Kumar
AU - Jha, Saurabh Kumar
N1 - Publisher Copyright:
© 2022 Bentham Science Publishers.
PY - 2022
Y1 - 2022
N2 - The inception of the COVID-19 pandemic has jeopardized humanity with markedly dam-pening of worldwide resources. The viral infection may present with varying signs and symptoms, imitating pneumonia and seasonal flu. With a gradual course, this may progress and result in the deadliest state of acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). More-over, following recovery from the severe brunt of COVID-19 infection, interstitial portions of alve-oli have been found to undergo residual scarring and further to have compromised air exchange. Such alterations in the lung microenvironment and associated systemic manifestations have been recognized to occur due to the extensive release of cytokines. The mortality rate increases with advancing age and in individuals with underlying co-morbidity. Presently, there is no availability of specific antiviral therapy or any other definitive modality to counter this progressive worsening. However, we believe principles and advancing cell-based therapy may prove fruitful in subjugating such reported worsening in these patients. This article reviews eminent knowledge and relevant ad-vancements about the amelioration of lung damage due to COVID-19 infection using adipose tis-sue-derived-total stromal fraction (TSF).
AB - The inception of the COVID-19 pandemic has jeopardized humanity with markedly dam-pening of worldwide resources. The viral infection may present with varying signs and symptoms, imitating pneumonia and seasonal flu. With a gradual course, this may progress and result in the deadliest state of acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). More-over, following recovery from the severe brunt of COVID-19 infection, interstitial portions of alve-oli have been found to undergo residual scarring and further to have compromised air exchange. Such alterations in the lung microenvironment and associated systemic manifestations have been recognized to occur due to the extensive release of cytokines. The mortality rate increases with advancing age and in individuals with underlying co-morbidity. Presently, there is no availability of specific antiviral therapy or any other definitive modality to counter this progressive worsening. However, we believe principles and advancing cell-based therapy may prove fruitful in subjugating such reported worsening in these patients. This article reviews eminent knowledge and relevant ad-vancements about the amelioration of lung damage due to COVID-19 infection using adipose tis-sue-derived-total stromal fraction (TSF).
KW - COVID-19
KW - Cytokines
KW - TSF
KW - adipose tissue-derived MSCs
KW - corona related pulmonary compromise
KW - total stromal fraction
UR - http://www.scopus.com/inward/record.url?scp=85148369203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85148369203&partnerID=8YFLogxK
U2 - 10.2174/2666796702666210908151708
DO - 10.2174/2666796702666210908151708
M3 - Review article
AN - SCOPUS:85148369203
SN - 2666-7967
VL - 3
SP - 56
EP - 64
JO - Coronaviruses
JF - Coronaviruses
IS - 1
M1 - e221221196287
ER -
